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Recombinant Bovine G1/S-specific cyclin-D1 (CCND1)

Recombinant Bovine G1/S-specific cyclin-D1 (CCND1)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Abbreviation

CCND1

Purity

>85% (SDS-PAGE)

Target Names

CCND1

Uniprot NO.

Q2KI22

Alternative Names

CCND1G1/S-specific cyclin-D1

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

1-295

Target Protein Sequence

MAHQLLCCEM ETIRRAYPDA NLLNDRVLRA MLKAEETCAP SVSYFKCVQK EILPSMRKIV ATWMLEVCEE QKCEEEVFPL AMNYLDRFLS LEPVKKSRLQ LLGATCMFVA SKMKETIPLT AEKLCIYTDN SIRPDELLHM ELVLVNKLKW NLAAMTPHDF IEHFLSKMPV AEENKQIIRK HAQTFVALCA TDVKFISNPP SMVAAGSVAA AAQGLHLGSA NGFLSYHRLT RFLSKVIRCD PDCLRACQEQ IEALLESSLR QAQQQNLDPK AAEEEEEEEE VDLACTPTDV RDVNI
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.

Gene References into Functions

CCND1 mRNA expression is increased by FGF9 in bovine theca cells and granulosa cells. PMID:27816766
cyclin D1, CDK2 and CDK4 are expressed in both caruncular and intercaruncular cells derived from both nonpregnant, and artificially inseminated cows on days 30 and 60 of gestation PMID:14967908
17beta-estradiol (E2) induces cell proliferation of bovine arterial endothelial cells through upregulation of cyclin D1 via non-genomic activation of the extracellular signal-regulated microtubule-associated Protein 2 kinase (ERK1 kinase) pathway. PMID:17454165

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Subcellular Location

Nucleus. Cytoplasm. Nucleus membrane.

Protein Families

Cyclin family, Cyclin D subfamily

Database Links

UNIGENE: Bt.88783

KEGG: bta:524530

STRING: 9913.ENSBTAP00000023277

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