Recombinant Bovine Follistatin (FST)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

FST

Uniprot NO.

P50291

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

30-344

Target Protein Sequence

G NCWLRQAKNG RCQVLYKTEL SKEECCSTGR LSTSWTEEDV NDNTLFKWMI FNGGAPNCIP CKETCENVDC GPGKKCRMNK KNKPRCVCAP DCSNITWKGP VCGLDGKTYR NECALLKARC KEQPELQVQY QGKCKKTCRD VFCPGSSTCV VDQTNNAYCV TCNRICPEPT SSEQYLCGND GVTYPSACHL RKATCLLGRS IGLAYEGKCI KAKSCDDIQC TGGKKCLWDF KVGRGRCSLC GELCPESKSE EPVCASDNAT YASECAMKEA ACSSGVLLEV KHSGSCNSIS EDTEDEEEDE DQDYSFPISS ILEW
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).

Gene References into Functions

Data suggest that SMAD4 (SMAD family member 4) mRNA is increased in oocytes during maturation, is maximal in 2-cell blastocysts, remains elevated through 8-cell stage, and then decreases; embryotrophic actions of FST are SMAD4 dependent. PMID:25031360
The expression of the components of the activin-inhibin-follistatin system is altered in bovine cystic ovarian disease. PMID:25001504
A functional role for oocyte-derived follistatin in bovine early embryogenesis. PMID:19179440

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Subcellular Location

Secreted.

Database Links

UNIGENE: Bt.405

KEGG: bta:327681

STRING: 9913.ENSBTAP00000004318

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