Recombinant Bovine Folate receptor alpha (FOLR1)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

FOLR1

Uniprot NO.

P02702

Alternative Names

FOLR1Folate receptor alpha; FR-alpha; Folate receptor 1; Folate-binding protein 1; FBP; Milk folate-binding protein

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

20-241

Target Protein Sequence

A QAPRTPRART DLLNVCMDAK HHKAEPGPED SLHEQCSPWR KNACCSVNTS IEAHKDISYL YRFNWDHCGK MEPACKRHFI QDTCLYECSP NLGPWIREVN QRWRKERVLG VPLCKEDCQS WWEDCRTSYT CKSNWHKGWN WTSGYNQCPV KAAHCRFDFY FPTPAALCNE IWSHSYKVSN YSRGSGRCIQ MWFDPFQGNP NEEVARFYAE NPTSGSTPQG I
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation.

Gene References into Functions

summarizes recent biochemical, analytical, food science, and nutritional advances regarding folate-binding protein in milk [REVIEW] PMID:22369260
ligand binding characteristics and aggregation behavior depends on the presence of amphiphatic substances [folate binding protein] PMID:12516784

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Subcellular Location

Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle. Endosome. Apical cell membrane.

Protein Families

Folate receptor family

Tissue Specificity

Detected in milk (at protein level).

Database Links

UNIGENE: Bt.62067

KEGG: bta:516067

STRING: 9913.ENSBTAP00000027602

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