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Recombinant Bovine Fatty acid synthase (FASN), partial

Recombinant Bovine Fatty acid synthase (FASN), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

FASN

Purity

>85% (SDS-PAGE)

Target Names

FASN

Uniprot NO.

Q71SP7

Alternative Names

FASNFatty acid synthase; EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S-acetyltransferase; EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase; EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase; EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase; EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase; EC 1.3.1.39); Oleoyl-[acyl-carrier-protein] hydrolase; EC 3.1.2.14)]

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

1-2513

Target Protein Sequence

MEEVVITGMS GKLPESENLE EFWANLIGGV DMVTDDDRRW KAGLYGLPRR SGKLKDLSRF DASFFGVHPK QAHNMDPQLR LLLEVTYEAI VDAGINPASI RGTNTGVWVG VSGSEASEAL SRDPETLVGY SMVGCQRAML ANRLSFFFDF KGPSITLDTA CSSSLLALQR AYQAIQRGEC AMAIVGGVNI RLKPNTSVQF MKLGMLSPEG TCKFFDASGN GYCRAKAVMA ILLTKKSLAR RVYATILNAG TNTDGCKEKG VTFPSGEAQE QLISSLYKPA GLDPETLEYV EAHGTGTKVG DPQELNGIVQ ALCGTRQSPL RIGSTKSNMG HPEPASGLAA LAKVLLSLEH GLWAPNLHFH NPNPKIPALQ DGRLQVVDRP LPVLGGNVGI NSFGFGGSNV HVILQPNSQP LPPPAPHAAL PRLLRASGRT LEGVQGLLEL GLQHSQNLAF VSMLNDIATP SPAAMPFRGY AVLGSQGGSQ KVQQVLAGKR PLWFICSGMG TQWRGMGLSL MRLSRFRDSI LRSDEAVKPL GLQVSQLLLS TDEAIFDDMV ISFVSLTAIQ IALIDLLTSM GLQPDGIIGH SLGEVACGYA DGCISQEEAI LSAYWRGQCI KEANIPPGAM AAVGLTWEEC KQRCPPGIVP ACHNCIDTVT ISGPQASMLE FVQQLKQEGV FAKEVRTGGM AFHSYFMDAI APMLLQQLKK VIREPQPRSP RWLSTSIPET QWQESLARTF SAEYNVNNLV SPVLFQEALW RVPEDAVVLE IAPHALLQAV LKRGLKSSCT IIPLMKKDHR DNLEFFLSNV GQLYLTGIDV NPNGLFPPVE FPAPRGTPLI SPHIKWDHSQ TWDVPTAEDF PSGSSSSSAT IYKIDINPES PDHYLVDHCI DGRIIFPGTG YLCLVWKTLA RALDQNMEHT PVVFEDVTLH QAVILPKTGI VLLKVRLLEA SCTFEVSENG NLIASGKVYQ WEDPNPKLFD NRYGPDPATP VDPTTAIHLS RGDVYKELQL QGFNYGPYFQ GILEASSEGN TGQLLWKDNW VTFMDTMLQM SILAPSKRSL RLPTRITAIY IHPATHQQKL YTLQDKTQVA DVVINRCLDT TVAGGIYISR IHTSVAPRHQ QEQLVPILEK FCFTPHVETG CLAGNLALQE ELQLCVGLAQ ALQTRVAQQG IKMVVPGLDG AQAPQEAPQQ GLPRLLATAC QLQLNGNLQM EMGQILAQER ALLCDDPLLS GLLNSPALKA CVTLALENMT SLKMKVVLAG DGQLYSRIPT LLNTQPLLEL DYTATDRHPQ ALEAAQAKLQ QLDITQGQWD PSDPAPSNLG GANLVVCNYA LASLGDPATA VGNMVAALKE GGFLLLHTLL RGHPLGETVT FLTCPEPQQG QRHLLSQDEW ERLFAGASLH LVALKKSFYG SVLFLCRRLA PLDSPIFLPV EDTSFQWVDS LKNILADSSS RAVWLMAVGC TTSGVVGLVN CLRKEPDGHR IRCVLVSNLN STSPIPETDP KSLELQKVLQ SDLVMNVYRD GAWGAFRHFP LEQDKPEEQT EHAFINVLTR GDLSSIRWVC SPLRHSQPTA PGFQLCTIYY ASLNFKRNHA GHGQAVPRRH PRNWASRNCL LGMEFSGRDA SGKRVMGLVP AEGLATSTLV PQSFLWDVPS NWTLEEAASV PVVYSTAYYA LMVRGRMQPG ETVLIHSGSG GVGQAAIAIA LSLGCRVFPL VGSAEKRAYL QSRFPQLNET SFANSRDTSF EQHVLWHTAG KGADLVLNSL AEEKLQASVR CLAQHGRFLE IGKFDLSKNH PLGMAIFLKN VTFHGILLDS LFEENNTMWQ EVSTLLKAGI RKGVVQPLKR TVFPRTQAED AFRYMAQGKH IGKVVIQVRE EEQEAVLHGT KPTQMVALCK TFCPAHKSYI ITGGLGGFGL ELAHWLVERG AQKLVLTSRS GIRTGYQARQ VHEWRRQGVQ VLVSTSDVST LDGTRSLITE AAQLGPVGGI FNLAVVLRDA MLDNQTPEFF QDVNKPKYNG TLNLDRVTRE ACPELDYFEV FSSVSCGRGN AGQTNYGFAN STMERICEKR RHDGLPGLAV QWGAIADVGL LMELKGTKDK AIGGTLPQRI TSCMEVLDLF LNQPHPVLSS FVLAEKATSR GPSGSHQDLV KAVTHILGIR DLATVNLDSS LSDLGLDSLM GVEVRQMLER EHNLLLSMRE IRQLTIHKLQ EISAQAGTAD ELTDSTPKFG SPAQSHTQLN LSTLLVNPEG PTLTRLNSVQ SSERPLFLVH PIEGSTTVFH SLATKLSIPT YGLQCTGAAP LDSIQSLATY YIECIRQVQP EGNYRIAGYS YGACVAFEMC SQLQAQQNAG PTNNSLFLFD GSHTFVMAYT QSYRAKLNPG CEAEAEAEAM CFFMQQFTEA EHSRVLEALL PLGDLEARVA ATVELIVQSH AGLDRHALSF AARSFYHKLR AAEEYTPRAT YHGNVTLLRA KMGSAYQEGL GADYNLSQVC DGKVSVHIIE GDHRTLLEGS GLESILSIIH SSLAEPRVSV REG
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.

Gene References into Functions

FASN single nucleotide polymorphisms associated with milk fatty acids in a Chinese Holstein cattle. PMID:27468856
g.841G>C SNP of FASN gene is associated with fatty acid composition in beef cattle. PMID:25597874
Results indicate that Fatty acid synthase (FASN) may be used as a candidate gene affecting intramuscular fat content in Datong yaks. PMID:25867409
It was suggested that two cattle breeds have an advantage in terms of genotype and haplotype distribution of the FASN gene; a single polymorphism might be a potential marker for breed discrimination. PMID:24745147
study evaluated the contributions of polymorphisms of FASN and SCD genes on fatty acid composition in muscle in two different populations: 1189 and 1058 Japanese Black cattle from the Miyagi and the Yamagata populations PMID:22497525
The five exonic single nucleotide polymorphisms of g.12870, g.13126, g.15532, g.16907, and g.17924 in the FASN gene could change fatty acid contents. PMID:21773945
Results suggest that SCD and FASN are strong candidate genes influencing fatty acid composition in beef cattle. PMID:22221030
The effects of genetic polymorphisms of liver X receptor, alpha (LXR), stearoyl-CoA desaturase (SCD), Fatty acid synthase (FASN), and Fatty acid binding protein 4 (FABP4) were investigated on fatty acid composition in fat tissue of steers. PMID:21615833
In ruminants, FASN may be regulated between the ratio between two transcripts. The small transcript is mostly produced in tissues with low fatty acid synthesis. PMID:16093723
Polymorphisms within the FASN gene are associated with milk-fat content. PMID:16734679
SNPs in the FASN gene are associated with variation in the fatty acid composition of adipose fat and milk fat. PMID:17242864
The four exons in FASN that encode for the TE domain were sequenced, and three SNPs, AF285607:g.17924A>G, g.18663T>C and g.18727C>T, were identified. PMID:18254736
These results demonstrate that the single nucleotide polymorphism alters the bovine FASN promoter activity in vitro and the Sp1/Sp3 binding ability of the sequence. PMID:18477667
Results suggest that the mutations may contribute to the characteristic fatty acid composition of Japanese Black beef. PMID:19291389