Recombinant Bovine Ezrin (EZR), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

EZR

Uniprot NO.

P31976

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

2-581

Target Protein Sequence

PKPINVRVT TMDAELEFAI QPNTTGKQLF DQVVKTIGLR EVWYFGLQYV DNKGFPTWLK LDKKVSAQEV RKESPLQFKF RAKFYPEDVA EELIQDITQK LFFLQVKEGI LSDEIYCPPE TAVLLGSYAV QAKFGDYNKE LHKAGYLGSE RLIPQRVMDQ HKLTRDQWED RIQVWHAEHR GMLKDSAMLE YLKIAQDLEM YGINYFEIKN KKGTDLWLGV DALGLNIYEK DDKLTPKIGF PWSEIRNISF NDKKFVIKPI DKKAPDFVFY APRLRINKRI LQLCMGNHEL YMRRRKPDTI EVQQMKAQAR EEKHQKQLER QQLETEKKRR ETVEREKEQM MREKEELMLR LQDYEEKTRK AEKELSDQIQ RALKLEEERK RAQEEAGRLE ADRLAALRAK EELERQAADQ IKSQEQLATE LAEYTAKIAL LEEARRRKEN EVEEWQLRAK EAQDDLVKTR EELHLVMTAP PPPPVYEPVN YHVHEGPQEE GTELSAELSS EGILDDRNEE KRITEAEKNE RVQRQLMTLT SELSQARDEN KRTHNDIIHN ENMRQGRDKY KTLRQIRQGN TKQRIDEFEA M
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.

Gene References into Functions

Ezrin and CK18 are downregulated during implantation in cattle. The expression changes represent a temporal depolarization, which could be important for an establishment of bovine pregnancy. PMID:26116960
Ezrin-dependent, membrane-specific translocation and activation of calpain by VEGF precedes AMPK and AKT-dependent phosphorylation of eNOSs1179 and production of NO. PMID:19038867

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Subcellular Location

Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cell projection, microvillus membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell projection, microvillus.

Tissue Specificity

Detected in eye lens fiber cells (at protein level).

Database Links

UNIGENE: Bt.3583

KEGG: bta:281574

STRING: 9913.ENSBTAP00000013663

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