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Recombinant Bovine Estrogen receptor (ESR1), partial

Recombinant Bovine Estrogen receptor (ESR1), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

ESR1

Uniprot NO.

P49884

Alternative Names

ESR1; ESR; NR3A1Estrogen receptor; ER; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

1-596

Target Protein Sequence

MTMTLHTKAS GMALLHQIQA NELEPLNRPQ LKIPLERPLG EVYMDSSKPA VYNYPEGAAY DFNAAAPASA PVYGQSGLPY GPGSEAAAFG ANGLGAFPPL NSVSPSPLVL LHPPPQPLSP FLHPHGQQVP YYLENESSGY AVREAGPPAY YRPNSDNRRQ GGRERLASTS DKGSMAMESA KETRYCAVCN DYASGYHYGV WSCEGCKAFF KRSIQGHNDY MCPATNQCTI DKNRRKSCQA CRLRKCYEVG MMKGGIRKDR RGGRMLKHKR QRDDGEGRNE AVPSGDMRAA NLWPSPIMIK HTKKNSPVLS LTADQMISAL LEAEPPIIYS EYDPTRPFSE ASMMGLLTNL ADRELVHMIN WAKRVPGFVD LALHDQVHLL ECAWLEILMI GLVWRSMEHP GKLLFAPNLL LDRNQGKCVE GMVEIFDMLL ATSSRFRMMN LQGEEFVCLK SIILLNSGVY TFLSSTLRSL EEKDHIHRVL DKITDTLIHL MAKAGLTLQQ QHRRLAQLLL ILSHFRHMSN KGMEHLYSMK CKNVVPLYDL LLEMLDAHRL HAPANFGSAP PEDVNQSQLA PTGCTSSHSL QTYYITGEAE NFPSTV
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3.

Gene References into Functions

our results here suggest that there is a negative correlation between bta-miR-222 and ER-alpha expression during follicular development in cow ovaries. PMID:29960859
The mRNA expression of ER-alpha and ER-beta in the hypothalamus of developing male and female bovines, is reported. PMID:25363750
Distribution of estrogen receptor alpha and progesterone receptor B in the bovine oviduct during the follicular and luteal phases of the sexual cycle: an immunohistochemical and semi-quantitative study PMID:20629585
ER-alpha is detected predominantly in the soma whereas ER-beta is only present in the nucleus of a few cells in the frontal cortex. PMID:21397601
Occurrence of a quadruplex motif in a unique insert within exon C of the bovine estrogen receptor alpha gene (ESR1 PMID:20715834
fetal ovary of cattle has the steroidogenic enzyme aromatase to convert androgens to estradiol-17beta, and estrogen receptors alpha and beta to facilitate an estrogen response within the fetal ovary PMID:19299095
there are different levels of ERalpha, ERbeta and PR in bovine oviducts at different cycle stages in vivo PMID:12711014
ER may play a role in the rapid effects of resveratrol in EC and some of the atheroprotective effects of resveratrol may be mediated through rapid activation of ER signaling in EC PMID:15615701
estrogen receptor alpha amounts within the intercaruncular uterine wall do not change during the peripartal period PMID:17223288
The expression of estrogen and progesterone receptors in ovarian follicular structures from cows with cystic ovarian disease (COD) and a comparison of these with normal ovarian structures are reported. PMID:17491080
These data indicate that PGF2alpha, TNFalpha and IFNgamma regulate ERalpha and ERbeta mRNA expressions in bovine luteal cells. PMID:17598955
The specific mRNA expression of ERalpha in various genotypes using real-time RT-PCR, was examined. PMID:17661161
Roles of IGF-I and the estrogen, androgen and IGF-I receptors in estradiol-17beta- and trenbolone acetate-stimulated proliferation of cultured bovine satellite cells. PMID:18403176