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Recombinant Bovine Early growth response protein 1 (EGR1), partial

Recombinant Bovine Early growth response protein 1 (EGR1), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

EGR1

Purity

>85% (SDS-PAGE)

Target Names

EGR1

Uniprot NO.

Q29W20

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

1-540

Target Protein Sequence

MAAAKAEMQL MSPLQISDPF GSFPHSPTMD NYPKLEEMML SNGAPQFLGA AGAPEGSSGS SSGSSGGGGG GGGGSSSSNS NSSSAFNPQG EASEQPYEHL TAESFPDISL NNEKVLVETS YPSQTTRLPP ITYTGRFSLE PAPNSGNTLW PEPLFSLVSG LVSMTNPPAT SSSASSPAAS SSASQSPPLS CAVQSNDSSP IYSAAPTFPT PNTDIFPEPQ GQAFPGSAGP ALQYPPPAYP GAKGGFQVPM IPDYLFPQQQ GDLGLGTPDQ KPFQGLESRT QQPSLTPLST IKAFATQSGS QDLKALNSTY QSQLIKPSRM RKYPNRPSKT PPHERPYACP VESCDRRFSR SDELTRHIRI HTGQKPQCRI SMRNFSRSDH LTTHIRTHTG EKPFACDICG RKFARSDERK RHTKIHLRQK DKKADKSAAS AATSSLPSYP SPVATSYPSP ATTSYPSPAT TSYPSPVPTS YSSPGSSTYP SPVHNGFPSP SVATTYSSVP PAFPTQVSSF PSSAVTNSFS ASTGLSDMTT TFSPRTIEIC
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary. Regulates the amplitude of the expression rhythms of clock genes: ARNTL/BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core-clock gene ARNTL/BMAL1 in the suprachiasmatic nucleus (SCN).

Gene References into Functions

Suggest that EGR1 is likely an upstream component of FGF signaling in granulosa cells. PMID:28733346
EGR1 can promote skeletal muscle satellite cell differentiation through positive regulation of MyoG gene expression. PMID:28256014
Chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling. PMID:22140445
The authors conclude that Egr-1 protein expression is very sensitive to upregulation by hypoxia in pulmonary artery adventitial fibroblasts and that it plays an important role in the autonomous growth phenotype induced by hypoxia in these cells. PMID:15475598
EGR-1's expression prior to ovulation and its stimulating effect on the expression of genes known to be involved in prostaglandin biosynthesis pathway, suggest its potential involvement in the regulation of preovulatory events in cattle. PMID:17032742