Recombinant Bovine Dynamin-2 (DNM2), partial

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MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

DNM2

Uniprot NO.

A6H7I5

Alternative Names

DNM2Dynamin-2; EC 3.6.5.5

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

1-866

Target Protein Sequence

MGNRGMEELI PLVNKLQDAF SSIGQSCHLD LPQIAVVGGQ SAGKSSVLEN FVGRDFLPRG SGIVTRRPLI LQLIFSKTEY AEFLHCKSRK FTDFEEVRQE IEAETDRVTG TNKGISPVPI NLRIYSPHVL NLTLIDLPGI TKVPVGDQPQ DIEYQIKDMI LQFISRESSL ILAVTPANMD LANSDALKLA KEVDPQGLRT IGVITKLDLM DEGTDARDVL ENKLLPLRRG YIGVVNRSQK DIEGKKDIRT ALAAERKFFL SHPAYRHIAD RMGTPHLQKT LNQQLTNHIR ESLPALRSKL QSQLLSLEKE VEEYKNFRPD DPTRKTKALL QMVQQFGVDF EKRIEGSGDQ VDTLELSGGA RINRIFHERF PFELVKMEFD EKDLRREISY AIKNIHGVRT GLFTPDLAFE AIVKKQVVKL KEPCLKCVDL VIQELINTVR QCTSKLSSYP RLREETERIV TTYIREREGR TKDQILLLID IEQSYINTNH EDFIGFANAQ QRSTQLNKKR AVPNQVIRRG WLTINNISLM KGGSKEYWFV LTAESLSWYK DEEEKEKKYM LPLDNLKIRD VEKGFMSNKH VFAIFNTEQR NVYKDLRQIE LACDSQEDVD SWKASFLRAG VYPEKDQAEN EDGAQENTFS MDPQLERQVE TIRNLVDSYV AIINKSIRDL MPKTIMHLMI NNTKAFIHYE LLAYLYSSAD QSSLMEESAD QAQRRDDMLR MYHALKEALN IIGDISTSTV STPVPPPVDD TWIQNTSSHS PTPQRRPVSS VHPPGRPPAV RGPTPGPPLI PVPVGPASFS APPIPSRPGP HPGVFANNDP FSAPPQIPSR PARIPPGIPP GVPSRRPPAA PSRPTIIRPA EPSLLD
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones. Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis. Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane.

Gene References into Functions

Dynamin-2 directs actin polymerization at the exocytosis site where both, in concert, adjust the hormone quantal release. PMID:23940613
role of the proline-rich domain of dynamin-2 in in vitro potentiation of endothelial nitric-oxide synthase activity. PMID:12488320
Knocking down dynamin-2 by small interfering RNA reduced both leukotoxin internalization and cytotoxicity. PMID:17682044
LKT-mediated cell death involve dynamin-2 and cyclophilin D PMID:18765728

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Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton. Cell junction. Membrane, clathrin-coated pit. Cell junction, synapse, postsynaptic density. Cell junction, synapse. Midbody. Cell projection, phagocytic cup. Cytoplasmic vesicle, phagosome membrane; Peripheral membrane protein.

Protein Families

TRAFAC class dynamin-like GTPase superfamily, Dynamin/Fzo/YdjA family

Database Links

UNIGENE: Bt.18482

KEGG: bta:511691

STRING: 9913.ENSBTAP00000035986

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