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Recombinant Bovine DNA damage-inducible transcript 4 protein (DDIT4)

Recombinant Bovine DNA damage-inducible transcript 4 protein (DDIT4)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

DDIT4

Purity

>85% (SDS-PAGE)

Target Names

DDIT4

Uniprot NO.

Q08E62

Alternative Names

DDIT4DNA damage-inducible transcript 4 protein

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

1-229

Target Protein Sequence

MPSLWDRFSS SSSSSSLSRT PTPNQPPRSA WGSAAREEGL GRCGSLESSD CESLDSSNSG FGPEEDSAYL DGVSLPDFEL LSDPEDEHLC ASLMQLLQES LAQARLGSRR PARLLMPGQL VSQVGKELLR LAYSEPCGLR GALLDVCVEQ GKSCHSVGQL ALDPSLVPTF QLTLVLRLDS RLWPKIQGLF SSANSPFVPG FSQSLTLSTG FRVIKKKLYS SEQLLIEEC
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes. Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death. Required for mTORC1-mediated defense against viral protein synthesis and virus replication.

Subcellular Location

Mitochondrion. Cytoplasm, cytosol.

Protein Families

DDIT4 family

Database Links

UNIGENE: Bt.2091

KEGG: bta:529235

STRING: 9913.ENSBTAP00000000187

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