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Recombinant Bovine Cyclin-dependent kinase 12 (CDK12), partial

Recombinant Bovine Cyclin-dependent kinase 12 (CDK12), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

CDK12

Uniprot NO.

E1BB50

Alternative Names

CDK12; Cyclin-dependent kinase 12; EC 2.7.11.22; EC 2.7.11.23; Cell division protein kinase 12

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

1-1264

Target Protein Sequence

MPNPERHGGK KDGSGGASGT LQPSSGGGSS NSRERHRLGS KHKRHKSKHS KDMGLVTPEA APLGTVIKPL VEYDDISSDS DTFSDDLAFK VDRRENDERR GTDRSDRLHK HRHHQHRRTR DLLKTKQTEK EKNLEASSKS GSTKDRISGS SKRSNEENDD HGKAQISKSS NKESRSSKLH KEKTRKEREL KSGHKDRSKS HRKRETPKSY KTVDSPKRRS RSPHRKWSDS PKQDDSPSGA SYGQDYDLSP PRSHTSSNYD SYKKSPGSTS RRQSISPPYK EPSAYQSSTR SPSPYSRRQR SVSPYSRRRS SSYERSGSYS GRSPSPYGRR RSSSPFLSKR SLSRSPLPSR KSMKSRSRSP AYSRHSSSHS KKKRSGSRSR HSSISPVRLP LNSSLGAELS RKKKERAAAA AAAKMDGKES KGSPIFLPKK ENSSVEAKDS GLEPKKLPRG VKLEKSAPDT ELVNVTHLNT EVKNSLDTGK VKLDENSEKH PVLKDTKVQG TKDSKPVALK EEIVTPKETE TSEKETLPPL PTVTSPPPLP TTTPPPQTPP LPPLPPLPAI PQQPPLPPPQ PTFSQVLSSS TSTLPPSVHP RTSTLSSQAN SQPSVQVSVK TQVSVTAAIP HLKTSTLPPL PLPPLLLGDD DMDSPKETLP SKPVKKEKEQ RPRHLLTDLP LPPELPGGDP SPPDSPEPKA ITPPQQPYKK RPKICCPRYG ERRQTESDWG KRCVDKFDII GIIGEGTYGQ VYKAKDKDTG ELVALKKVRL DNEKEGFPIT AIREIKILRQ LIHRSVVNMK EIVTDKQDAL DFKKDKGAFY LVFEYMDHDL MGLLESGLVH FSEDHIKSFM KQLMEGLDYC HKKNFLHRDI KCSNILLNNS GQIKLADFGL ARLYNSEESR PYTNKVITLW YRPPELLLGE ERYTPAIDVW SCGCILGELF TKKPIFQANL ELAQLELISR LCGSPCPAVW PDVIKLPYFN TMKPKKQYRR RLREEFSFFF LPWGALDLLD HMLTLDPSKR CTAEQTLQSD FLKDVELSKM DPPDLPHWQD CHELWSKKRR RQRQSGVLVE EPPPPKASRK ETISGTSAEP VKNSSPAPPQ PAPGKVEPGA GDAIGLGDIT QQLNQSELAV LLNLLQSQTD LSIPQMAQLL NIHSNPEMQQ QLEALNQSIS ALTAATSQQQ DSEPTAPEES LKEIAPAPAV QPSAEQTTPE ASSTPADMQN MLAVLLSQLM KTQEPAGNLE ENNSDKNSGP QGPRRTPTMP QEEAAGKQTG HESH
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.

Subcellular Location

Nucleus. Nucleus speckle.

Protein Families

Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily

Database Links

UNIGENE: Bt.67418

STRING: 9913.ENSBTAP00000002005

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