Home
Product
Protein
Recombinant Proteins
Recombinant Bovine Cyclic AMP-responsive element-binding protein 1 (CREB1)

Recombinant Bovine Cyclic AMP-responsive element-binding protein 1 (CREB1)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

CREB1

Uniprot NO.

P27925

Alternative Names

CREB1; CREB; CREB2Cyclic AMP-responsive element-binding protein 1; CREB-1; cAMP-responsive element-binding protein 1; Cyclic AMP-responsive DNA-binding protein

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

1-325

Target Protein Sequence

MESGAENQQS GDAAVTEAES QQMTVQAQPQ IATLAQVSMP AAHATSSAPT VTLVQLPNGQ TVQVHGVIQA AQPSVIQSPQ VQTVQISTIA ESEDSQESVD SVTDSQKRRE ILSRRPSYRK ILNDLSSDAP GVPRIEEEKS EEETSAPAIT TVTVPTPIYQ TSSGQYIAIT QGGAIQLANN GTDGVQGLQT LTMTNAAATQ PGTTILQYAQ TTDGQQILVP SNQVVVQAAS GDVQTYQIRT APTSTIAPGV VMASSPALPT QPAEEAARKR EVRLMKNREA ARECRRKKKE YVKCLENRVA VLENQNKTLI EELKALKDLY CHKSD
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

Submit a Review here

Target Background

Function(From Uniprot)

Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-117 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.

Gene References into Functions

Data indicate that Ser738/742-to-glutamate protein kinase D mutant increased AngII-induced CREB protein and activating transcription factor 2 phosphorylation, and phospho-CREB binding to the steroidogenic acute regulatory protein promoter. PMID:24708239
SUMO-1 has a role in modifying cAMP-response element-binding protein CREB in prolonged hypoxia. PMID:12552083
dsRNA as well as other agonists of endothelial cells elicit signaling mechanisms that include in part CREB phosphorylation mediated by calcium-independent phospholipase A2 PMID:12810819
the p38-MAPK/CREB pathway plays a critical role in TNFalpha-induced VCAM-1 expression PMID:16715652