Recombinant Bovine Caveolin-1 (CAV1)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

CAV1

Uniprot NO.

P79132

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

2-178

Target Protein Sequence

SGGKYVDSE GHLYTVPIRE QGNIYKPNNK AMAEEMNEKQ VYDAHTKEID LVNRDPKHLN DDVVKIDFED VIAEPEGTHS FDGIWKASFT TFTVTKYWFY RLLSALFGIP MALIWGIYFA ILSFLHIWAV VPCIKSFLIE IQCISRVYSI YVHTFCDPLF EAIGKIFSNI RINTQKEI
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation.

Gene References into Functions

Caveolin-1 scaffolding domain residue phenylalanine 92 modulates Akt signaling PMID:26409042
Data show that resveratrol (Res) reversed caveolin-1 (Cav-1)/endothelial nitric oxide synthase (eNOS) expressions in high glucose cultured bovine aortic endothelial cells (BAECs). PMID:25419974
these data provide the first detailed analysis of Cav-1 binding to one of its most significant client proteins, eNOS. PMID:24648521
Study identifies a critical role of caveolin-1 in the regulation of eNOS uncoupling via a biopterin-dependent mechanism. PMID:21724868
Data indicate that caveolin-1 expression is required for insulin uptake by aortic endothelial cells. PMID:20959538
caveolin-1 is not required for the targeting of signaling molecules to caveolae/lipid rafts PMID:15292187
integrin activation with shear stress results in SFK-regulated caveolin-1 phosphorylation that, in turn, mediates Csk association at integrin sites, where it plays a role in downstream, shear-stimulated myelin light chain diphosphorylation. PMID:15471980
importance of CAV1 amino acids 89-95 and particularly F92 in mediating eNOS inhibition by AP-Cav and Cav-1 PMID:15637154
When endothelial cells were exposed to shear stress, caveolin-1 was transiently dephosphorylated. PMID:16325778
alphaCAV1 likely contributes to control the increase in membrane signaling that occurs at the time of ovulation and luteinization. PMID:16894547
caveolin-1 tyrosine 14 phosphorylation has a role in cell adhesion and migration PMID:17868074
caveolin-1 Tyr(14) is necessary for binding to intermediate filaments, which in turn is required for anterior polarization of caveolin-1 in transmigrating cells PMID:17955336
Phosphorylation of CAV1 in bovine rod outer segments in vitro by an endogenous tyrosine kinase is reported. PMID:18188962
XIAP plays a novel role in endothelial cells, interacting with caveolin-1 and acting as a regulator of vascular antiatherogenic function. PMID:18309102
These data show that insulin acutely regulates eNOS and CAV-1 trafficking to plasma membrane of vascular endothelial cells where their interaction can regulate eNOS activity. PMID:19608646
TGF-beta1 downregulates caveolin-1 of cultured endothelial cells, involving ALK-5 receptor subtype PMID:19710365

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Subcellular Location

Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft.

Protein Families

Caveolin family

Database Links

UNIGENE: Bt.106571

KEGG: bta:281040

STRING: 9913.ENSBTAP00000023751

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