Recombinant Bovine Apelin (APLN)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

APLN

Purity

>85% (SDS-PAGE)

Target Names

APLN

Uniprot NO.

Q9TUI9

Alternative Names

APLN; APELApelin; APJ endogenous ligand) [Cleaved into: Apelin-36; Apelin-31; Apelin-28; Apelin-13]

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

42-77

Target Protein Sequence

LVQPRGPRS GPGPWQGGRR KFRRQRPRLS HKGPMPF
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Cytoplasmic domain

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Endogenous ligand for the apelin receptor (APLNR). Drives internalization of APLNR. Apelin-36 dissociates more hardly than (pyroglu)apelin-13 from APLNR. Hormone involved in the regulation of cardiac precursor cell movements during gastrulation and heart morphogenesis. Has an inhibitory effect on cytokine production in response to T-cell receptor/CD3 cross-linking; the oral intake of apelin in the colostrum and the milk might therefore modulate immune responses in neonates. Plays a role in early coronary blood vessels formation. Mediates myocardial contractility in an ERK1/2-dependent manner. May also have a role in the central control of body fluid homeostasis by influencing vasopressin release and drinking behavior.

Gene References into Functions

APJ receptor in granulosa cells and both apelin and the APJ receptor in theca tissues are expressed in bovine ovary. PMID:19223129
The data suggest that apelin/APJ system is involved in the mechanism regulating angiogenesis during follicle maturation as well as during corpora lutea formation and function in the bovine ovary. PMID:19461937

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Subcellular Location

Secreted. Secreted, extracellular space.

Protein Families

Apelin family

Database Links

UNIGENE: Bt.495

KEGG: bta:282143

STRING: 9913.ENSBTAP00000026630

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