Recombinant Bovine Annexin A2 (ANXA2)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

ANXA2

Uniprot NO.

P04272

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

2-339

Target Protein Sequence

STVHEILCK LSLEGDHSTP PSAYGSVKAY TNFDAERDAL NIETAIKTKG VDEVTIVNIL TNRSNEQRQD IAFAYQRRTK KELASALKSA LSGHLETVIL GLLKTPAQYD ASELKASMKG LGTDEDSLIE IICSRTNQEL QEINRVYKEM YKTDLEKDIV SDTSGDFRKL MVALAKGRRA EDGSVIDYEL IDQDARDLYD AGVKRKGTDV PKWISIMTER SVCHLQKVFE RYKSYSPYDM LESIKKEVKG DLENAFLNLV QCIQNKPLYF ADRLYDSMKG KGTRDKVLIR IMVSRSEVDM LKIRSEFKKK YGKSLYYYIQ QDTKGDYQKA LLYLCGGDD
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9.

Gene References into Functions

ClfA binds with AnnexinA2 and this interaction could mediate S. aureus invasion into bovine mammary epithelial cells. PMID:28102235
AnxA2 functions as a critical regulator for amino acid or hormone-induced milk synthesis and mammary gland epithelial cell proliferation via the PI3K-mTOR-SREBP-1c/Cyclin D1 signaling pathway. PMID:28771726
annexin A2-induced actin bundling is apparently essential for generating active exocytotic sites. PMID:26323692
Annexins A1 and A2 are proteins produced by airway epithelial cells that may prevent inflammation in the healthy lung and be relevant to development of pneumonia in stressed cattle. PMID:25827591
Calves that later developed pneumonia had significantly lower levels of annexin A1 and annexin A2, which are potential biomarkers of increased susceptibility to pneumonia in recently weaned and transported feedlot cattle. PMID:23565988
Because annexins I and II are abundant and have functions important to the maintenance of placentation, the down-regulation of the annexin genes in the cultured NT (nuclear transfer) trophectoderm may be related to the frequent failures of NT pregnancies. PMID:20400246
annexin II binds to CEACAM1 in a breast neoplasm model PMID:14522961
show for the first time that annexin A2 (AIIt) can undergo functional reactivation by glutaredoxin, therefore establishing that AIIt is regulated by reversible glutathionylation PMID:14668336
AII does not bind 1,25-D(3) in a physiologically relevant manner PMID:14991775
Data show that the mRNA-binding site of Annexin A2 resides in its domain IV. PMID:17395201
The results showed that alkaline phosphatase (ALP) activity was significantly increased in matrix vesicles from calcified bovine vascular smooth muscle cells (BVSMCs) compared with noncalcified BVSMCs, as was annexin II and VI content and (45)Ca uptake. PMID:18597635