Home
Product
Protein
Recombinant Proteins
Recombinant Bovine Angiopoietin-related protein 4 (ANGPTL4)

Recombinant Bovine Angiopoietin-related protein 4 (ANGPTL4)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Abbreviation

ANGPTL4

Purity

>85% (SDS-PAGE)

Target Names

ANGPTL4

Uniprot NO.

Q2KJ51

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

24-410

Target Protein Sequence

QGRPEPP ETPRFASWDE VNVLAHGLLQ LGHGLREHVE RTRGQLGELE RRLGACGAAC KDPEGSAAPP RAQANLVNPG GGDASPETLR SLKTQLEAQN SRIQQLFQKV AQQQRHLEKQ QLRIQNLQSQ MDHLAPRHLG HEMAKPARRK RLPKMAQLAG PAHNISRLHR LPRDCQELFE EGERESGLFQ IQPQGSPPFL VNCKMTSDGG WTVIQRRQDG SVDFNQPWEA YKDGFGDPQG EFWLGLEKVH HILGDRGSRL AVQLQDWEGN AESLQFPIHL GGEDTAYSLQ LTPPVASKLG ATTFSPSGLS LPFSTWDQDH DLRGDKNCAR SLSGGWWFGT CSHSNLNGQY FHSIPRQRQQ RKKGIFWKTW RGRYYPLQAT TILVQPTAAS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

Submit a Review here

Target Background

Function(From Uniprot)

Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro). Depending on context, may modulate tumor-related angiogenesis.; Mediates inactivation of the lipoprotein lipase LPL, and thereby plays an important role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. Has higher activity in LPL inactivation than the uncleaved protein.

Gene References into Functions

increase in angiopoietin-like protein 4 messenger RNA across multiple models of altered energy balance identifies it as an adipokine that is uniquely responsive to changes in energy balance in the lactating dairy cow PMID:22683322
These findings indicate that liver and adipose tissue are key sources of ANGPTL4 in cattle; the protein was also highly abundant in ruminal epithelium, making it possible that commensal microbes may influence ANGPTL4 synthesis and secretion. PMID:19783696

Hide All

Subcellular Location

Secreted. Secreted, extracellular space, extracellular matrix.

Database Links

UNIGENE: Bt.4816

KEGG: bta:509963

STRING: 9913.ENSBTAP00000003204

Promotions