Recombinant Bovine Angiopoietin-2 (ANGPT2)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

ANGPT2

Uniprot NO.

O77802

Alternative Names

ANGPT2; ANG2Angiopoietin-2; ANG-2

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

19-496

Target Protein Sequence

HS GSRKGMDIAA GKKQYQVQHG ACSYTFLLPE TDHCRSPSSA YVPNAVQRDA PLDYDDSVQR LQVLENIMEN NTQWLMKLEN YIQDNMKKEM VEIQQNAVQN QTAVMIEIGT NLLNQTAEQT RKLTDVEAQV LNQTTRLELQ LLEHSLSTNK LEKQILDQTS EISKLQDKNS FLEKKVLDME DKHIVQLRSI KEEKDQLQVL VSKQNSIIEE LEKQLVTATV NNSVLQKQQH DLMETVNNLL TLMSTSNPSY SLLAKDEQII FRDCGEAFKS GLTTSGVYTL TFPNSTEEIK AYCDMETGGG GWTVIQRRED GSVDFQRTWK EYKVGFGNPS GEHWLGNEFV SQVTGQKRYV LKIHLRDWEG NEAYSLYDHF YLSNEELNYR IHLKGLTGTA GKISSISQPG NDFSTKDADN DKCICKCSQM LTGGWWFDAC GPSNLNGMYY PQRQNTNKFN GIKWYYWKGS GYSLKATTMM IRPADF
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating angiogenic signals mediated by ANGPT1. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.

Gene References into Functions

polymorphisms significantly associated with milk somatic cell score PMID:23726425
Hypoxic regulation of Ang-2 is HIF-dependent and demonstrate that HIF-1alpha binds in human microvascular endothelial cells (HMVEC) to an evolutionary conserved Hypoxia-Responsive Element (HRE) located in the first intron of the Ang-2 gene. PMID:18720385
The mRNA expression for ANPT-2 was drastically decreased in the follicles with E(2)>5 ng/ml. PMID:15329480
Activation of the PI3-K/Akt pathway downregulates Angiopoietin-2 reveals an additional mechanism through which the PTEN/PI3-K/Akt pathway could affect the angiogenic process. PMID:16447257
Ang2 produced by oscillatory shear stress in endothelial cells plays a critical role in migration/tubule formation. May have role in diseases with disturbed flow/angiogenesis. PMID:17673702
In mature and late regressing corpus luteum, high scores of Ang-2-immunopositive endothelial and smooth muscle cells were found. PMID:18541291