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Recombinant Bovine Alpha-2-macroglobulin (A2M), partial

Recombinant Bovine Alpha-2-macroglobulin (A2M), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

A2M

Purity

>85% (SDS-PAGE)

Target Names

A2M

Uniprot NO.

Q7SIH1

Alternative Names

A2MAlpha-2-macroglobulin; Alpha-2-M

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

24-1510

Target Protein Sequence

SVSGKPQ YMVLVPSLLH TETPEKGCLL LSHLNETVTV SASLESVREN RSLFTDVVAE KDLFHCVSFT LPRSPTSQEV MFLTIQVKGP TQEFKKRTTV LVKNEESLVF VQTDKPIYKP EQTVKFRIVL LDESFHPLNE LVPLVYVEDP KGNRIAQWQN LEVENGLQQL TFPLSSEPFQ GSYKVVVQKG SGGTAEHPFT VEEFVLPKFE VQVRMPKIIT ILEEEVQVSV CGLYTYGKPV PGRVTMNMCR KYRNPSNCYG EESNAVCEKF SGELNNEGCF SQQVNTKIFQ LKRQEFEMKI EVEAKIQEEG TEVELTGKGA TEITTTITKL SFVTVDSNLR RGIPFTGKVL LVDGKGVPMP NKVIFITANE ANHNSNTTTD EHGLAQFSIT TTKIKGTSLS IRVKYKDHSP CYGYQWLSEE HQDAYHSANL VFSRSNSFVY LEPLPRELPC GKTQTVQAHY VLKGQVLKDL KELVFYYLIM AKGGIVRSGT HTLPVEQGDM QGHFSMSVPV ESDIAPVARL LIYAILPDGE VVGDSARYEI EHCLANKVGL NFSPGQSFPA SQAHLRVTAS PQSLCALRAV DQSVLLMRPE AELSAATVYN LLPVKDLSSF PSSVNQQEED NEDCISHDNV YINGIMYFPV SNTNEKDMYS FLQDMGLKAF TNSKIHKPKI CPQPEEHRIQ HHTLLASPVR AEMGRNRDFV HFDDTSEPPT ETVRKYFPET WIWDLVVVSS SGVHEVEVTV PDTITEWKAG ALCLSRDTGL GLSPTASLRV FQPFFVELTM PYSVIRGEAF TLKATVLNYL PKCIRVSVQL EASPAFLAVP EKEQETYCIC GNGRQTVSWA VTPKSLGNVN FTVSAEAVES QELCGSEVPV VPEHGRKDTI IKPLLVEPEG LEKEVIFNSL LCPSVDFVFL GAEDGGQVLR HFPPAAATDT AADAHDPARP GAKVSESLSL KLPPNVVEES ARASFSVLGD ILGSAMRNTQ NLLQMPYGCG EQNMARFAPN IYVLDYLNET QQLTAELKSK AILYLNTGYQ RQLLYKHFDG SYSTFGEHRG NSEGNTWLTA FVLKSFAQAR GYIFIDEAHI TEALTWLAQK QKSNGCFRST GTLLNNAIKG GVDDEVTLSA YITIALLEMP LPVTHPVVRN ALFCLDSAWK SAKEGSQGSH VYTKALLAYA FALAGNQERR TEVLTSLYEE AVKEDNTIHW TRPQKPRLLT EDIYQPRAPS AEVEMTAYVI LAHVTAQPAP NPEDLKRATS IVKWISKQQN CQGGFSSTQD TVVALHALSR YGAATFTSAR KAAQVTIQSS GTFSTKFQVE NSNRLLLQQV SLPEVPGEYS MSVTGEGCVY LQTSLKYNIL PKKDEFPFAL EVQTLPQTCD GPKAHTSFQI SLSVSYIGSR PASNMAIVDV KMVSGFIPLK PTVKMLERSN VSRTEVSNNH VLIYLDKVTN ETLTLTFTVL QDIPVRDLKP AIVKVYDYYE TDEFAVAEYS APCSKDIGNA
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

Gene References into Functions

Mutations in the promoter region and the 3'-untranslated region of the A2M gene are involved in the mastitis susceptibility in dairy cows. PMID:25237709
We report here for the first time the direct isolation of Spp24 covalently bound to alpha2-macroglobulins as a core complex (Spp24-alpha2M) from bovine calf serum. PMID:22949401
Exon 29 c.3535A>T in the alpha-2-macroglobulin gene causing aberrant splice variants is associated with mastitis. PMID:22923050
These results suggest the possible involvement of cathepsin E in disruption of the structural and functional integrity of alpha 2-macroglobulin in the endolysosome system. PMID:12631277
Alpha2-macroglobulin is a substrate and an endogenous inhibitor for ADAMTS-4 and ADAMTS-5 PMID:14715656
Amounts of alpha(2)-M receptor in granulosa cells were strongly inversely associated with concentrations of estradiol in dominant and subordinate follicles. PMID:15001551