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Recombinant Bovine Aggrecan core protein (ACAN), partial

Recombinant Bovine Aggrecan core protein (ACAN), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

ACAN

Uniprot NO.

P13608

Alternative Names

ACAN; AGC1Aggrecan core protein; Cartilage-specific proteoglycan core protein; CSPCP

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

17-2364

Target Protein Sequence

AISV EVSEPDNSLS VSIPEPSPLR VLLGSSLTIP CYFIDPMHPV TTAPSTAPLA PRIKWSRISK EKEVVLLVAT EGRVRVNSAY QDKVTLPNYP AIPSDATLEI QNMRSNDSGI LRCEVMHGIE DSQATLEVVV KGIVFHYRAI STRYTLDFDR AQRACLQNSA IIATPEQLQA AYEDGFHQCD AGWLADQTVR YPIHTPREGC YGDKDEFPGV RTYGIRDTNE TYDVYCFAEE MEGEVFYATS PEKFTFQEAA NECRRLGARL ATTGQLYLAW QGGMDMCSAG WLADRSVRYP ISKARPNCGG NLLGVRTVYL HANQTGYPDP SSRYDAICYT GEDFVDIPES FFGVGGEEDI TIQTVTWPDV ELPLPRNITE GEARGSVILT AKPDFEVSPT APEPEEPFTF VPEVRATAFP EVENRTEEAT RPWAFPREST PGLGAPTAFT SEDLVVQVTL APGAAEVPGQ PRLPGGVVFH YRPGSSRYSL TFEEAKQACL RTGAIIASPE QLQAAYEAGY EQCDAGWLQD QTVRYPIVSP RTPCVGDKDS SPGVRTYGVR PPSETYDVYC YVDRLEGEVF FATRLEQFTF WEAQEFCESQ NATLATTGQL YAAWSRGLDK CYAGWLADGS LRYPIVTPRP ACGGDKPGVR TVYLYPNQTG LLDPLSRHHA FCFRGVSAAP SPEEEEGSAP TAGPDVEEWM VTQVGPGVAA VPIGEETTAI PGFTVEPENK TEWELAYTPA GTLPLPGIPP TWPPTGEATE EHTEGPSATE VPSASEKPFP SEEPFPPEEP FPSEKPFPPE ELFPSEKPFP SEKPFPSEEP FPSEKPFPPE ELFPSEKPIP SEEPFPSEEP FPSEKPFPPE EPFPSEKPIP SEEPFPSEKP FPSEEPFPSE EPSTLSAPVP SRTELPSSGE VSGVPEISGD FTGSGEISGH LDFSGQPSGE SASGLPSEDL DSSGLTSTVG SGLPVESGLP SGEEERITWT SAPKVDRLPS GGEGPEVSGV EDISGLPSGG EVHLEISASG VEDISGLPSG GEVHLEISAS GVEDLSRIPS GEGPEISASG VEDISGLPSG EEGHLEISAS GVEDLSGIPS GEGPEVSASG VEDLIGLPSG EGPEVSASGV EDLSRLPSGE GPEVSASGVE DLSGLPSGEG PEVSVSGVED LSRLPSGEGP EVSASGVEDL SRLPSGEGPE ISVSGVEDIS ILPSGEGPEV SASGVEDLSV LPSGEGHLEI STSGVEDLSV LPSGEGHLET SSGVEDISRL PSGEGPEVSA SGVEDLSVLP SGEDHLEISA SGVEDLGVLP SGEDHLEISA SGVEDISRLP SGEGPEVSAS GVEDLSVLPS GEGHLEISAS GVEDLSRLPS GGEDHLETSA SGVGDLSGLP SGREGLEISA SGAGDLSGLT SGKEDLTGSA SGALDLGRIP SVTLGSGQAP EASGLPSGFS GEYSGVDLES GPSSGLPDFS GLPSGFPTVS LVDTTLVEVV TATTAGELEG RGTIDISGAG ETSGLPFSEL DISGGASGLS SGAELSGQAS GSPDISGETS GLFGVSGQPS GFPDISGETS GLLEVSGQPS GFYGEISGVT ELSGLASGQP EISGEASGIL SGLGPPFGIT DLSGEAPGIP DLSGQPSGLP EFSGTASGIP DLVSSAVSGS GESSGITFVD TSLVEVTPTT FKEEEGLGSV ELSGLPSGEL GVSGTSGLAD VSGLSSGAID SSGFTSQPPE FSGLPSGVTE VSGEASGAES GSSLPSGAYD SSGLPSGFPT VSFVDRTLVE SVTQAPTAQE AGEGPSGILE LSGAPSGAPD MSGDHLGSLD QSGLQSGLVE PSGEPASTPY FSGDFSGTTD VSGESSAATS TSGEASGLPE VTLITSELVE GVTEPTVSQE LGQRPPVTYT PQLFESSGEA SASGDVPRFP GSGVEVSSVP ESSGETSAYP EAEVGASAAP EASGGASGSP NLSETTSTFH EADLEGTSGL GVSGSPSAFP EGPTEGLATP EVSGESTTAF DVSVEASGSP SATPLASGDR TDTSGDLSGH TSGLDIVIST TIPESEWTQQ TQRPAEARLE IESSSPVHSG EESQTADTAT SPTDASIPAS AGGTDDSEAT TTDIDECLSS PCLNGATCVD AIDSFTCLCL PSYQGDVCEI QKLCEEGWTK FQGHCYRHFP DRATWVDAES QCRKQQSHLS SIVTPEEQEF VNNNAQDYQW IGLNDKTIEG DFRWSDGHSL QFENWRPNQP DNFFATGEDC VVMIWHEKGE WNDVPCNYQL PFTCKKGTVA CGEPPVVEHA RIFGQKKDRY EINALVRYQC TEGFIQGHVP TIRCQPSGHW EEPRITCTDP ATYKRRLQKR SSRPLRRSHP STAH
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.

Gene References into Functions

the subsequent presentation of aggregan from ECM leads to CD4(+) T-cell activation and effector cell formation. PMID:24032649
Data show that expression of mRNAs for aggrecan, collagen type II, and versican were significantly effected by the intervention. PMID:21289569
The delayed activation of proMMPs and the relatively low cleavage efficiency of MMPs compared to ADAMTS5 (aggrecanase) explains the minor contribution of the MMP enzymes to aggrecan catabolism in vivo. PMID:21055468
Self-adhesion between highly negatively charged aggrecan macromolecules extracted from bovine cartilage extracellular matrix, was investigated. PMID:21081100
aggrecanase activity (a) is responsible for early TNFalpha-dependent aggrecan cleavage and GAG release in the meniscus and (b) might be involved in meniscal degeneration. PMID:19778432
Maintenance of structure and organization of extracellular matrix comprising chondron and pericellular microenvironment of chondrocytes in articular cartilage is important for distribution of newly synthesized aggrecan monomers within tissue. PMID:12475642
aggrecan plays a protective role in preventing degradation of collagen fibrils PMID:12890681
Changes in aggrecan and type II collagen promoter activity in transfected chondrocyte-laden cylindrical constructs were evaluated in response to a range of loading frequencies and durations. PMID:16691412
AGC1 mRNA expression level was upregulated by multidirectional articular motion. PMID:17518631
Homozygosity mapping in candidate regions in a small Dexter pedigree suggested aggrecan as the most likely candidate gene. Mutation screening revealed a 4-bp insertion in exon 11 (2266_2267insGGCA) and a second, rarer transition in exon 1 (-198C>T). PMID:17952705
identified multiple conserved amino acids within regions N- and C-terminal of aggrecan to the site of scission that may influence enzyme-substrate recognition, and may interact with exosites on ADAMTS-4 and ADAMTS-5 PMID:19101611
The objective of this study was to compare patterns of aggrecan processing by chondrocytes and meniscal fibrochondrocytes in tissue explants and cell-agarose constructs. PMID:19260779