Recombinant Bovine Activin receptor type-2A (ACVR2A), partial

Product Details

Abbreviation
ACVR2A
Purity
>85% (SDS-PAGE)
Target Names
ACVR2A
Uniprot NO.
Alternative Names
ACVR2A; ACTRII; ACVR2Activin receptor type-2A; EC 2.7.11.30; Activin receptor type IIA; ACTR-IIA
Species
Bos taurus (Bovine)
Source
Yeast
Protein Length
Partial
Tag Info
N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Storage Condition
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

 Customer Reviews

Target Background

Function(From Uniprot)
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6.
Gene References into Functions
  1. miRNA-424/503 cluster members target the SMAD7 and ACVR2A genes which are involved in the activin signalling pathway PMID:29716627
  2. This genome-wide association study identified variants in the upstream region of ACVR2A, which were associated with female fertility in Japanese Black cattle. PMID:26486459

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Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Families
Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
Database Links

UNIGENE: Bt.513

KEGG: bta:281598

STRING: 9913.ENSBTAP00000024108

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