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Recombinant Bovine AT-rich interactive domain-containing protein 5B (ARID5B), partial

Recombinant Bovine AT-rich interactive domain-containing protein 5B (ARID5B), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

ARID5B

Uniprot NO.

E1BLP6

Alternative Names

ARID5BAT-rich interactive domain-containing protein 5B; ARID domain-containing protein 5B

Species

Bos taurus (Bovine)

Source

Yeast

Expression Region

1-1173

Target Protein Sequence

MEPNSLQWVG SPCGLHGPYI FYKAFQFHLE GKPRILSLGD FFFVRCTPKD PICIAELQLL WEERTSRQLL SSSKLYFLPE DTPQGRNSDH GEDEVIAVSE KVIVKLEDLV KWVHSDFSKW RCGLQAGSVK TESLGRNGQK EALLKYRQST LNSGLNFKDV LKEKADLDCL GEDEEETNVI VLSYPQYCRY RSMLKRIQDK PSSILTDQFA LALGGIAVVS KNPQILYCRD TFDHPTLIEN ESICDEFAPN LKGRPRKKKP CPQRRDSFSG GKDPNNNSDG KSVAKVKCEA RSALNKPKNN HNNCKKVSNE EKPKVAIGEE CRADEQAFLV ALYKYMKERK TPIERIPYLG FKQINLWTMF QAAQKLGGYE TITARRQWKH IYDELGGNPG STSAATCTRR HYERLILPYE RFIKGEEDKP LPPIKPRKQE NNSQENENKT KVSGAKRIKH EISKSKKEKE NAPKPQDASE VSSEQEKEQE TVNQKSITEP LPIADTKKKL EGYQDFAARP LVSQADPEKD SETDQGANSE KVAEEAGEKG PAPPLASAPL APTPGTGKQS LTSPSALVDS KEPKPCCFTE SPENELQEAS FPGFSTTQPP LANQSEVEDD KLPAMADYIA NCTVKVDQLG SDDIHNALKQ TPKVLVVQSF DMFKDKDLTG PMNENHGLNY TPLLYSRGNP GIMSPLAKKK LLSQVSGASL SSSYPYGSPP PLISKKKVIA REDRCSSLSQ AHHGQSTDHM AVNRPSVIQH VQSFRSKPSE ERKISDIFKH DKLSRSEPRF SFSKHHLSPS KKSRGRRTVE KRALPHSHMP SFLADFYSSP HLHSLYRHTE HHLHNEQTSK YPCRDMYRET ENSSFPSHKH QEKLHVNYLA SLHLQDKKSA AVEAPTDDQP TDLSLPKNPH KPTGKALGLA HSAPGPQESK GTSQFQVINS QSRDCHPKAC RVSPMTMSAP KKYPEALSRS GKPHPVRLEN FRKMDSMVHP ILHRKMSPQN IGAARPIKRS LEDLDLVIAG KKARAVSPLD PAKEVSGKEK ASEQESEGSK AAHSGHSGGT SEGHKLPLSS PIFPGLYSGS LCSSGLNSRL PAGYSHSLQY LKNQAVLSPL MQPLAFHSLV MQRGIFTSPT NSQQLYRHLA AATPVGSSYG DLLHNSIYPL AAINPQAAFP SSQLSSVHPS TKL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-340, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation.

Subcellular Location

Nucleus.

Protein Families

ARID5B family

Database Links

STRING: 9913.ENSBTAP00000008847

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