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Recombinant Arabidopsis thaliana Serine/threonine-protein kinase ATR (ATR), partial

Recombinant Arabidopsis thaliana Serine/threonine-protein kinase ATR (ATR), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

ATR

Purity

>85% (SDS-PAGE)

Target Names

ATR

Uniprot NO.

Q9FKS4

Species

Arabidopsis thaliana (Mouse-ear cress)

Source

Yeast

Expression Region

1-2702

Target Protein Sequence

MAKDDNNLSS LVHELRERVA ASASTPANNL RHSSGDEDAL EIRFRAVIPN LLNTYVVPSL GNGREVTAVL KLVGHTARNI PGVFYHGTPS AILPVIARII PFFAEPEFVP GHGVLLETVG SLLMLLRSNS RKAYRIFFHD ALQAIQDMQP IASLHSIEPE VCESHIPFRC FCMSFSGIGG DLPDANKPRD GDGLVLNLLG ANRWQPFATC ILKLICKCLT EGTLYVQGLI HTSFFKAACS LVCCGGADVQ MACFEFATLV GSILTFNILP HVALIQSIIL LLSADEGLPV YRNTIYDSTI GRFLTAVYSS CSDAAVKLTA ESLVLVLSHA LQRTKSEELK ASLCSAYVRI VKSCPPCIWK IHCLLELLHL PEPCFQLIEC FKAVLIVLGP GCVRVETTKC GSHTSATSDR PVQGINAGKK RHIEDESTYK RKRQKVGDDI RRGVYFAPEF ADETDGKDAA SLREMLISTV ESLKPPPAGP SLSQTESSIV ALSMLTNAFC FCPWTDMTHR LFNQMYAWIP WIAGQVEETN PIMFDISIYL EGIHNLLLVG VDPQYEYTSK GNDLVAIQFL LKLPWTHYML FKTPSSLVKS KCLSVGIWTK LGLQDGSDFD IFSWSLSDDF EQVQAVAAIS MPLKVLFSGL GALLHMFPKL EHLLEEKELM IKKAIPQSLG FLSCLYGSST TDSEKTACHL LLHEDLKKDE TLNSLLQGFR CSKCDKFIER EDEKHFRIIE TPEMVKLKMD HHRDYFNLQS LYFNLLYDES SEETQLACVE VIRRILGHTS PDILVRTRSQ WIRCLQYLLV HVNTDVREAF CAQIGIFVQH PIVSCLFLSE DATEKSCERN FFNLIEHSLA AAKDLLVIQT LLETTAEVMV AVDVTSELFL ICLFLLIDQL DHPNLIVRIN ASKLINRSCY IHVKGGFATL LSTASHIQNE LFDNLSVRLT SRPNVVREFA EAVLGVETEE LVRKMVPAVL PKLLVYWQEN AQAANTLNEL AKLIDTDVVP LIVNWLPRVL AFALNQEEDK NLLSVLQLYH SQIGSDNQEI FAAALPALLD ELVCFVDIAD TPETDRRLQR LPDAIKKISK VLTNAEDLPG FLQNHFVGLL NSIDRKMLHA DDIFLQKQAL KRIKLLIEMM GHYLSTYVPK LMVLLMHAIE KDALQSEGLL VLHFFTRKLA DVSPSSIKYV ISQIFAALIP FLEKEKEGPH VYLDEVVKIL EELVLKNRDI VKEHICEFPL LPSIPSLGEL NNAIQEARGL MSLKDQLRDI VNGMKHENLN VRYMVACELS KLLYNRNEDV AALIAGELVS DMEILSSLIT YLLQGCAEES RTTVGQRLKL VCADCLGAIG AIDPAKVRVA SCSRFKIQCS DDDLIFELIH KHLARAFRAA QDTIIQDSAA LAIQELLKIA GCEPSLAGNV VVLTPQEHVQ VNVSGSRRCG GNNEVKDRGQ KLWDRFSNYV KELIAPCLTS RFQLPNVSDP GSAGPIYRPS MSFRRWLSYW IRKLTAFATG SRVSIFAACR GIVRHDMQTA TYLLPYLVLD VVCHGTEAAR LSISEEILSV LDAAASENSG VTINSFGVGQ SEVCVQAVFT LLDNLGQWVD DVKQGVALSS SLQSSGGRQV APKSKDQVSN STTEQDHLLV QCKYVLELLL AIPKVTLARA SFRCQAYARS LMYLESHVRG KSGSLNPAAE KTGIFENADV SSLMGIYSCL DEPDGLSGFA SLSKSLNLQD QLLINKKSGN WADVFTACEQ ALQMEPTSVQ RHSDVLNCLL NMCHHQTMVT HVDGLISRVP EYKKTWCTQG VQAAWRLGKW DLMDEYLDGA DAEGLLFSSS DSNASFDRDV AKILHAMMKK DQYSVAEGIA ISKQALIAPL AAAGMDSYTR AYPFVVKLHL LRELEDFQAV LNGDSYLEKS FSTSDQVFSK AVDNWENRLR FTQSSLWTRE PLLAFRRLVF GASGLGAQVG NCWLQYAKLC RLAGHYETAH RAILEAQASG APNVHMEKAK LLWITKRSDS AIIELQQSLL NMPEGVVDST VISSINSLLM APPNPEPTVR NTQSFKEKKD VAKTLLLYSK WIHHSGQKQK KDVLNLYTQV KELLPWEKGY FHLAKYYDEL YVDARKCQQE SSVFSSAGSK KGSVSSNLST EKAGWDYLFK GMYFYAKALH SGHKNLFQAL PRLLTLWFDF GTIYKTSGSA GNKELKSTHM KIMSLMRGCL KDLPTYQWLT VLPQLVSRIC HQNADTVLMV KNIITSVLHQ FPQQGLWIMA AVSKSTVPAR REAAAEIIQG ARKGFNQSDR GHNLFIQFAS LTDHFIKLCF HGGQPRSKVI NIATEFSALK RMMPLDIIMP IQQSLTISLP AFHMNNNERH SASVFSGSDL PTISGIADEA EILSSLQRPK KIILLGNDGI EYPFLCKPKD DLRKDARMME FTAMINRLLS KYPESRRRKL YIRTFAVAPL TEDCGLVEWV PHTRGLRHIL QDIYISCGKF DRQKTNPQIK RIYDQCAVKK EYEMLKTKIL PMFPPVFHKW FLTTFSEPAA WFRSRVAYAH TTAVWSMVGH IVGLGDRHGE NILFDSTSGD CVHVDFSCLF DKGLQLEKPE LVPFRLTQNM IDGLGITGYE GIFMRVCEIT LTVLRTHRET LMSILETFIH DPLVEWTKSH KSSGVEVQNP HAQRAISSIE ARLQGVVVGV PLPVEGQARR LIADAVSLEN LGKMYIWWMP WF
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Probable serine/threonine kinase. Plays a central role in cell-cycle regulation by transmitting DNA damage signals to downstream effectors of cell-cycle progression. May recognize the substrate consensus sequence [ST]-Q and phosphorylate histone variant H2AX to form H2AXS139ph at sites of DNA damage, thereby regulating DNA damage response mechanism. Seems to be required for the G2-phase checkpoint in response to replication blocks but not absolutely required in the G2-arrest response to double-strand breaks. May also be involved in the meiosis process. Required for the basal expression of RNR1 (ribonucleotide reductase large subunit). Acts in concert with telomerase to maintain telomeric DNA tracts. Not required for telomere length homeostasis. Required for effective immune responses that involve activation of DNA damage responses.

Gene References into Functions

ATR function together with SOG1 and ALT2 to halt root growth and promote terminal differentiation in response to chronic Aluminum exposure. PMID:26320227
Data suggest that an RNA G-quadruplex of the G(3)L(1-7) class resides in the 5prime-untranslated region of ATR mRNA and appears to function in down-regulation of mRNA translation. PMID:25793418
Data show that the ATM-SOG1 and ATR-SOG1 pathways both transmit DSB-derived signals and that either one suffices for endocycle induction. PMID:21613568
The MRN complex is essential for activation of the ATM and ATR kinases in response to irradiation. PMID:20876831
Both ATM and ATR contribute to the induction of a CYCB1;1:GUS fusion by IR, but only ATR is required for the persistence of this response. [ATR] PMID:17227549
Aluminum-dependent root-growth inhibition primarily arises from DNA damage coupled with AtATR-controlled blockage of cell-cycle progression and terminal differentiation because of loss of the root-quiescent center. PMID:18835170