gag Antibody, FITC conjugated

Code: CSB-PA356017DC01MHK

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50μg100μg

US$166

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Species Reactivity: Moloney murine leukemia virus

Raised in: Rabbit

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Target Background

Product Details

Uniprot NO.

P03332

Target Names

gag

Alternative Names

gag antibody; Gag polyprotein antibody; Pr65gag antibody; Core polyprotein) [Cleaved into: Matrix protein p15 antibody; MA); RNA-binding phosphoprotein p12 antibody; pp12); Capsid protein p30 antibody; CA); Nucleocapsid protein p10-Gag antibody; NC-gag)] antibody

Raised in

Rabbit

Species Reactivity

Moloney murine leukemia virus

Immunogen

Recombinant Moloney murine leukemia virus Gag polyprotein protein (216-478AA)

Immunogen Species

Moloney murine leukemia virus

Conjugate

FITC

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Plays a role in budding and is processed by the viral protease during virion maturation outside the cell. During budding, it recruits, in a PPXY-dependent or independent manner, Nedd4-like ubiquitin ligases that conjugate ubiquitin molecules to Gag, or to Gag binding host factors. Interaction with HECT ubiquitin ligases probably links the viral protein to the host ESCRT pathway and facilitates release.; Targets Gag and gag-pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the pre-integration complex.; Constituent of the pre-integration complex (PIC) which tethers the latter to mitotic chromosomes.; Forms the spherical core of the virion that encapsulates the genomic RNA-nucleocapsid complex.; Involved in the packaging and encapsidation of two copies of the genome. Binds with high affinity to conserved UCUG elements within the packaging signal, located near the 5'-end of the genome. This binding is dependent on genome dimerization.

Gene References into Functions

The structure of the minimal sequence of the murine leukemia virus p12 protein necessary for the host chromatin binding was elucidated. PMID:27707926
Phosphorylation requirement of murine leukemia virus p12 virus p12 protein necessary for the host chromatin binding was elucidated. PMID:27707931
The N-terminal intracellular domain of the glycoGag is responsible for its effect on HIV-1 infectivity. PMID:24403584
Authors found that mature Gag proteins MA and TM were bound to the immature core consisting of the Gag polyprotein (PrGag) and viral RNA (vRNA). PMID:23643491
in presence of nucleocapsid (NC) chaperone, RNA dimerization occurred rapidly through a single structural intermediate; NC interacted primarily with guanosine residues; results show RNA chaperones can simplify RNA folding landscapes by weakening intramolecular interactions involving guanosine PMID:23470731
selective packaging of dimeric RNA is explained by the nucleic acid binding domain derived from Gag binding within the virus to the sequence UCUG-UR-UCUG PMID:20974908
results suggest a cooperative effect of p12 and capsid during the early events of MLV replication PMID:15767417
interaction of Gag with Tsg101 and Alix favors budding from the plasma membrane and relieves a requirement for ubiquitination by Nedd4 PMID:15908698
results indicate that glycosylated gag protein is important for M-MuLV replication in vivo and in vitro and that the protein may be involved in a late step in viral budding or release PMID:17267509
Abl protein contribute to proper localization by playing a dominant role in trafficking of the v-Abl molecule PMID:18367522
Basal budding and replication of the murine leukemia virus are independent of the gag L domains PMID:18667521

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Subcellular Location

[Gag polyprotein]: Virion. Host cell membrane; Lipid-anchor. Host late endosome membrane; Lipid-anchor. Host endosome, host multivesicular body.; [Matrix protein p15]: Virion.; [Capsid protein p30]: Virion.; [Nucleocapsid protein p10-Gag]: Virion.; [RNA-binding phosphoprotein p12]: Host cytoplasm.

Database Links

KEGG: vg:1491870

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