cyp125 Antibody

CSB-PA351308HA01MVZ

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US$83

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Species Reactivity: Mycobacterium tuberculosis

Raised in: Rabbit

Application: ELISA

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Product Details
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Target Background

Product Details

Uniprot NO.

P9WPP1

Target Names

cyp125

Alternative Names

cyp125 antibody; cyp125A1 antibody; Rv3545c antibody; MTCY03C7.11Steroid C26-monooxygenase antibody; EC 1.14.15.29 antibody; Cholest-4-en-3-one 26-monooxygenase antibody; Cholest-4-en-3-one C26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming] antibody; Cholesterol C26-monooxygenase antibody; Cholesterol C26-monooxygenase [(25S)-3beta-hydroxycholest-5-en-26-oate forming] antibody; Cytochrome P450 125 antibody; Steroid C27-monooxygenase antibody

Raised in

Rabbit

Species Reactivity

Mycobacterium tuberculosis

Immunogen

Recombinant Mycobacterium tuberculosis Steroid C26-monooxygenase protein (1-433AA)

Immunogen Species

Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Tested Applications

ELISA

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Protocols

ELISA Protocol

Datasheet & COA

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Description

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Target Background

Function

Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain during infection. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25S)-26-hydroxycholest-4-en-3-one (alcohol), (25S)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25S)-3-oxocholest-4-en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en-3-one.

Gene References into Functions

M. tuberculosis cytochrome P450 Cyp125 plays a key role in cholesterol metabolism being involved in the first steps of its degradation PMID:26197389
Drug modulation of water-heme interactions in low-spin P450 complexes of CYP2C9d and CYP125A1. PMID:25591012
CYP125A1 plays a crucial role in circumventing the deleterious effect of cholest-4-en-3-one. PMID:20545858
Reactive nitrogen species (*NO) produced by host macrophages binds to CYP125 in its ferric state; a role for *NO in inhibition of cytochrome P450 activities in dormant mycobacterial cells is conceivable. PMID:19146393
Mycobacterial cytochrome p450 125 (cyp125) catalyzes the terminal hydroxylation of c27 steroids. PMID:19846551
The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection. PMID:19846552