ZMYND8 Antibody

Code: CSB-PA026517GA01HU

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Size:

100μl

US$600

Quantity:

Species Reactivity: Human,Mouse,Rat

Raised in: Rabbit

Application: ELISA,IHC

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Target Background

Product Details

Uniprot NO.

Q9ULU4

Target Names

ZMYND8

Alternative Names

ZMYND8 antibody; KIAA1125 antibody; PRKCBP1 antibody; RACK7 antibody; Protein kinase C-binding protein 1 antibody; Cutaneous T-cell lymphoma-associated antigen se14-3 antibody; CTCL-associated antigen se14-3 antibody; Rack7 antibody; Zinc finger MYND domain-containing protein 8 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human ZMYND8

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,IHC

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

May act as a transcriptional corepressor for KDM5D. Required for KDM5D-mediated down-regulation of diverse metastasis-associated genes; the function seems to involve the recognition of the dual histone signature H3K4me1-H3K14ac. Suppresses prostate cancer cell invasion.

Gene References into Functions

Drebrin may regulate activities of epigenetic reader ZMYND8 via its cytoplasmic sequestration. PMID:28966017
The MYND domain of ZMYND8 directly interacts with PPPLPhi motifs in the NuRD subunit GATAD2A. PMID:27732854
Single domain disruptions destroy the functional network of interactions initiated by ZMYND8, impairing recruitment to sites of DNA damage. Our data establish a proof of principle that rigidity can be compensated by concomitant DNA and histone post-translational-modifications (PTMs) interactions, maintaining multivalent engagement of transient chromatin states. PMID:27926874
KDM5A demethylates H3K4 to allow ZMYND8-NuRD to operate within damaged chromatin to repair DNA double strand breaks. PMID:28572115
ZMYND8's PHD-Bromo cassette couples H3K4me1-H3K14ac with downregulation of metastasis-linked genes in prostate tumor cells. PMID:27477906
a dual histone reader ZMYND8 (zinc finger MYND (Myeloid, Nervy and DEAF-1)-type containing 8), was identified to be a novel target of all trans retinoic acid. PMID:28232094
Data suggest that epithelial-mesenchymal transition (EMT) is regulated by ZMYND8 (receptor for activated protein kinase C) which selectively activates gene promoters of CLDN1 (claudin 1) and CDH1 (E-cadherin) in breast cancer cells; thus, the presence of ZMYND8 could be implicated in maintaining epithelial phenotype of cells; ZMYND8 regulates invasion/migration of breast cancer cells. PMID:28432260
Findings reveal a RACK7/KDM5C-regulated, dynamic interchange between histone H3K4me1 and H3K4me3 at active enhancers, representing an additional layer of regulation of enhancer activity. Authors propose that RACK7/KDM5C functions as an enhancer "brake" to ensure appropriate enhancer activity, which, when compromised, could contribute to tumorigenesis. PMID:27058665
study identifies that ZMYND8 has CHD4-independent functions in regulating gene expression through its modified histone-binding ability. PMID:26655721
identified ZMYND8 (zinc finger and MYND [myeloid, Nervy, and DEAF-1] domain containing 8) as a novel DDR factor that recruits the nucleosome remodeling and histone deacetylation (NuRD) complex to damaged chromatin PMID:25593309
ZMYND8 induces vegfa mRNA expression selectively in prostate cancer xenografts. PMID:25117453