ZIC1 Antibody

Code: CSB-PA795975

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Size:

100μl

US$297

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Species Reactivity: Human,Mouse

Raised in: Rabbit

Application: ELISA,WB,IHC

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Target Background

Product Details

Uniprot NO.

Q15915

Target Names

ZIC1

Alternative Names

Odd paired homolog Drosophila antibody; Zic 1 antibody; ZIC antibody; Zic family member 1 (odd-paired Drosophila homolog) antibody; Zic family member 1 antibody; Zic protein member 1 antibody; zic1 antibody; ZIC1_HUMAN antibody; Zinc finger protein 201 antibody; Zinc finger protein of the cerebellum 1 antibody; Zinc finger protein ZIC 1 antibody; Zinc finger protein ZIC1 antibody; ZNF 201 antibody; ZNF201 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthesized peptide derived from internal of Human ZIC1/2/3.

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA,WB,IHC

Protocols

ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western blot analysis of extracts from Jurkat cells and COLO cells, using ZIC1/2/3 antibody.
Immunohistochemistry analysis of paraffin-embedded human brain tissue using ZIC1/2/3 antibody.

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Target Background

Function(From Uniprot)

Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'.

Gene References into Functions

Study demonstrate that ZIC1 plays a tumor suppressive role in breast cancer, by targeting surviving, significantly downregulating its expression. PMID:29956756
Two proposed mechanisms for Zic-mediated cerebellar developmental control have been documented: regulation of neuronal progenitor proliferation-differentiation and the patterning of the cerebellar primordium. Clinical studies have also revealed that ZIC1 gain of function mutations contribute to coronal craniosynostosis, a rare skull malformation. PMID:29442326
By unbiased genome-wide DNA methylation profiling and comprehensive stepwise verification and validation studies using in vitro and patient-derived samples, we identified 3 promising methylation markers (GHSR, SST, and ZIC1) associated with a 3q gain for the detection of cervical (pre)cancer PMID:28119363
down-regulated expression of ZIC1 contributed to the inhibition of cell proliferation, and inhibited the growth of tumor PMID:26670443
our results suggest that the Zic1 promoter methylation rate in plasma-derived DNA is of great significance for the early screening of gastric cancer and monitoring of tumorigenesis PMID:26207911
Gain-of-Function Mutations in ZIC1 Are Associated with Coronal Craniosynostosis and Learning Disability. PMID:26340333
ZIC1 might play a role in the development of Ovarian Cancer, and may be a therapeutic target in OC. PMID:25953442
aberrant methylation is an important mechanism for ZIC1 inactivation in Hepatocellular carcinoma (HCC). PMID:24782033
ZIC1 is frequently inactivated by promoter hypermethyaltion and functions as a tumor suppressor in thyroid cancer through modulating PI3K/Akt and MAPK signaling pathways and transcription factor FOXO3a. PMID:24684457
Loss of ZIC1 expression is associated with malignant pleural mesothelioma. PMID:24457242
Methylation of ZIC1, a putative tumor suppressor, may be a novel determinant of ovarian cancer outcome PMID:23774800
Zic transcription factors function in patterning hindbrain motor neurons through their regulation of embryonic retinoic acid signaling PMID:23937294
Overexpression of ZIC1 results in inactivation of Shh, PI(3)K and MAPK signaling pathways, as well as regulation of multiple downstream targets which are essential for the development and progression of gastric cancer. PMID:22799764
ZIC1 may potentially function as a tumor suppressor gene PMID:21347233
The down-regulated expression of ZIC1 and KLOTHO in colorectal carcinoma may relate to promoter methylation. PMID:21671493
Dandy-Walker malformation associated with heterozygous ZIC1 and ZIC4 deletion. PMID:21204220
ZIC1, ZIC2, and ZIC5 may have roles in meningiomas PMID:20199689
ZIC1 contributes to the pathogenesis of liposarcoma. ZIC1 knockdown inhibits proliferation, reduces invasion, and induces apoptosis in dedifferentiated and myxoid/round cell liposarcoma cell lines. PMID:20713527
zic-1-mediated transcription is repressed by the intracellular domain of teneurin-2 PMID:12783990
ZIC1 was excluded from playing a causal role in most cases of JS (Joubert syndrome) as no disease-associated mutations were identified. PMID:14981711
Through physical mapping of 3q2 interstitial deletions in several individuals with Dandy-Walker malformation (DWM), we defined the first critical region associated with DWM, encompassing two adjacent Zinc finger in cerebellum genes, ZIC1 and ZIC4. PMID:15338008
this is the first report describing ZIC1 expression in mesenchymal proliferations and a role for DNA methylation in the control of ZIC1 expression. PMID:17936758
Study investigated the effect of an evolutionarily conserved GQ from the mRNA of the zinc-finger protein of the cerebellum 1 (Zic-1); the motif was found to drastically repress translation without affecting the mRNA level in vivo. PMID:18515550
These results revealed ZIC1 as a novel candidate tumor suppressor gene downregulated through promoter hypermethylation in gastric cancer. PMID:19135984

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Subcellular Location

Nucleus. Cytoplasm.

Protein Families

GLI C2H2-type zinc-finger protein family

Tissue Specificity

CNS. A high level expression is seen in the cerebellum. Detected in the nuclei of the cerebellar granule cell lineage from the progenitor cells of the external germinal layer to the postmigrated cells of the internal granular layer. Detected in medullobla

Database Links

HGNC: 12872

UNIGENE: Hs.598590

KEGG: hsa:7545

STRING: 9606.ENSP00000282928

OMIM: 600470

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