WDR73 Antibody, Biotin conjugated

Code: CSB-PA744047LD01HU

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Size:

50μl100μl

US$166

Quantity:

Species Reactivity: Human

Raised in: Rabbit

Application: ELISA

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Target Background

Product Details

Uniprot NO.

Q6P4I2

Target Names

WDR73

Alternative Names

WDR73 antibody; HSPC264WD repeat-containing protein 73 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human WD repeat-containing protein 73 protein (163-366AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Biotin

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

May play a role in the regulation of microtubule organization and dynamics.

Gene References into Functions

We expanded the clinical phenotype of GMS with WDR73 gene defect to include retinal dysfunction with missense mutation and developmental dysplasia of the hip. PMID:29929488
WDR73 as a candidate gene of severe intellectual disability and cerebellar hypoplasia. PMID:27983999
We document postnatal onset of CA, a retinopathy, basal ganglia degeneration, and short stature as novel features of WDR73-related disease, and define WDR73-related disease as a new entity of infantile neurodegeneration. PMID:26123727
Nonsense mutation in the WDR73 gene is associated with Galloway-Mowat syndrome PMID:25873735
WDR73 interacts with mitotic microtubules to regulate cell cycle progression, proliferation and survival in brain PMID:26070982
WDR73 plays a crucial role in the maintenance of cell architecture and cell survival. PMID:25466283

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Subcellular Location

Cytoplasm, cytosol. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Cleavage furrow.

Protein Families

WD repeat WDR73 family

Tissue Specificity

Expressed in kidney and brain. In the kidney, expressed in glomeruli, most probably in podocytes, and in tubules (at protein level). In the brain, expressed in the cerebellum, with high levels in Purkinje cells and their projecting axons, in the deep cere

Database Links

HGNC: 25928

UNIGENE: Hs.745027

KEGG: hsa:84942

STRING: 9606.ENSP00000387982

OMIM: 251300

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