Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.
Gene References into Functions
High plasma VEGF-B levels are associated with type 2 diabetes mellitus.PMID:28523459
Data from clinical studies point out the changes in circulating or tissue expression levels of VEGF-B in obese compared with lean patients.PMID:28798193
Cardiac transgenic vascular endothelial growth factor-B overexpression failed to protect heart transplants from ischemia-reperfusion injury.PMID:27588416
renal VEGF-B expression correlates with the severity of Diabetic Kidney Disease.PMID:28190774
Data show that metformin treatment reduces serum vascular endothelial growth factor B (VEGF-B) levels and ameliorates insulin resistance.PMID:26387747
Frameshift mutations of VEGFB gene is associated with stomach and colorectal cancers.PMID:25633991
fluid shear stress induces the synthesis of Insulin growth factor-2 and vascular endothelial growth factor (VEGF) B and D, which in turn transactivate MMP-12.PMID:25435370
MMP9 may activate VEGF-B via PI3K/Akt signaling pathway.PMID:25424698
Roles of vascular endothelial growth factor in amyotrophic lateral sclerosis.PMID:24987705
Low VEGFB and VEGFD gene expression is associated with early-stage non-small cell lung cancer.PMID:24145997
Our study suggested that VEGF-B was an angiogenesis factor in vitro and that ERK1/2 and p38-related signaling pathways were involved in these VEGF-B activities.PMID:24374930
VEGF-B has possible roles in cardiac protection, energy metabolism support, and neuroprotectin [review]PMID:24987005
High VEGF-B levels might correlate with the presence of hyperlipidemia and target organ damage in type 2 diabetic patients.PMID:25001655
High VEGFB expression is associated with bone marrow metastasis in neuroblastoma.PMID:23553333
VEGF-B might be an important ligand in the signalling between the tumor and preexisting blood vessels to ensure a functional blood supply for tumor survival.PMID:23417498
we report significant associations with overall survival and distant failure for certain VEGF(VEGF-B) family members.PMID:23728940
Data indicate that three miRs (miR-484, -642, and -217) were able to predict chemoresistance and vasculature of serous epithelial ovarian carcinomas through the regulation of the VEGFB and VEGFR2 pathways.PMID:23697367
Expression of VEGF-B genes in glioma cell lines U87 is significantly changed under hypoxia and ischemic conditions.PMID:23350126
In WT1 mutant cells, reduced VEGF(165)b was due to lack of WT1-mediated transcriptional repression of the splicing-factor kinase SRPK1PMID:22172722
analysis of binding of vascular endothelial growth factor-B by VEGFR-1(D2)PMID:20501651
TIMP3 blocks the binding of VEGF to VEGF receptor-2 and inhibits downstream signaling and angiogenesis.PMID:12652295
Results describe the crystal structure of human vascular endothelial growth factor-B (VEGF-B) and present a predicted model for the association of VEGF-B with the second domain of its receptor, VEGFR-1.PMID:16616187
Basophils could play a role in angiogenesis and inflammation through the expression of several forms of VEGF-B and their receptors.PMID:17082651
VEGFB, and receptor were highly expressed in dysplastic neurons. IR in astroglial and balloon cells was observed for VEGFA and its receptors Double-labeling also showed expression of VEGFA, VEGFB and VEGFR-1 in cells of the microglia/macrophage lineage.PMID:18317782
VEGF-B appears to have a relatively restricted angiogenic activity in the ischemic heart.PMID:18511699
Increased VEGFB expression is associated with hepatocellular carcinomaPMID:18537151
Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy.PMID:18757827
The structural features of the 'highly ordered' interaction of the Fab fragment of the antibody (Fab-2H10) with VEGF-B, is presented.PMID:18930733
VEGF-B mRNA was not expressed either in normal urothelium or in bladder cancer.PMID:19424629
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Subcellular Location
Secreted. Note=Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.
Protein Families
PDGF/VEGF growth factor family
Tissue Specificity
Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas.