VDAC2 Antibody, FITC conjugated

Code: CSB-PA025824LC01HU

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50μg100μg

US$166

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Species Reactivity: Human

Raised in: Rabbit

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Target Background

Product Details

Uniprot NO.

P45880

Target Names

VDAC2

Alternative Names

B-36 vdac antibody; FLJ23841 antibody; hVDAC2 antibody; OTTHUMP00000019878 antibody; OTTHUMP00000019879 antibody; OTTHUMP00000019880 antibody; Outer mitochondrial membrane protein porin 2 antibody; POR antibody; Porin-2 antibody; VDAC 2 antibody; VDAC-2 antibody; VDAC2 antibody; VDAC2_HUMAN antibody; Vdac6 antibody; Voltage dependent anion channel 2 antibody; Voltage dependent anion selective channel protein 2 antibody; Voltage-dependent anion-selective channel protein 2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Voltage-dependent anion-selective channel protein 2 protein (2-36AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol. Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway.

Gene References into Functions

VDAC2 ensures mitochondria-specific membrane association of Bax and in the absence of VDAC2 Bax localizes towards other cell compartments. Bax retrotranslocation is also regulated by nucleotides and calcium ions, suggesting a potential role of the transport of these ions through VDAC2 in Bax retrotranslocation. PMID:27620692
High methylation of the VDAC2 promoter CpGs in men with asthenospermia PMID:27892527
Chinese men carrying VDAC2 variants may have a decreased or increased risk of abnormal semen parameters associated with male infertility. PMID:27806320
The evolutionary demand for the NTE in the presence of cysteines clearly emerges from our biochemical and functional studies, providing insight into factors that functionally demarcate hVDAC-2 from the other VDACs. PMID:26487717
Motifs of VDAC2 required for mitochondrial Bak import and tBid-induced apoptosis. PMID:26417093
Results show that in thyroid tumours and cell lines, VDAC2 is upregulated and BAK1 downregulated. Also, transient knockdown of VDAC2 promoted upregulation of the BAK1 expression, and increased susceptibility to sorafenib treatment. PMID:25617717
RACK1 plays an antiapoptotic role during IBDV infection via interaction with VDAC2 and VP5. PMID:25583988
GSK-3beta translocates from the cytosol to mitochondria in a kinase activity- and VDAC2-dependent manner in which an N-terminal domain of GSK-3beta may function as a mitochondrial targeting sequence PMID:25187518
Cysteine residues impact the stability and micelle interaction dynamics of the human mitochondrial beta-barrel anion channel VDAC-2. PMID:24642864
minor conformational variations in local residues are sufficient to define the membrane protein dynamics in hVDAC-2. PMID:23873934
The reconstitution of functional VDAC-2 in lauryldimethylamine-oxide (LDAO) detergent micelles and 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) lipid bilayer nanodiscs, is reported. PMID:22119777
Binding of VDAC2 enhances eNOS activity in the pulmonary circulation. PMID:22842492
VP5-induced apoptosis during IBDV infection is mediated by interacting with VDAC2, a protein that appears to restrict viral replication via induction of cell death PMID:22114330
distribution and function of VDAC2 in human spermatozoa PMID:21347391
VDAC2 may facilitate mitochondrial Ca(2+) uptake and restrict Ca(2+) spark expansion without regulating activations of sparks under resting conditions. PMID:21241999
The high abundance of VDAC2 mRNA seemed to have a positive correlation with low sperm motility in male infertility with idiopathic asthenozoospermia. PMID:20809416
VDAC2 and VDAC3 might have an alternative structural organization and different functions in outer dense fibers than in mitochondria PMID:14739283
VDAC-2 inhibits the Bak-mediated apoptotic response via Bax PMID:15757910
Results identify VDAC2 and aldolase A as membrane proteins of K562 cells with increased expression under iron deprivation. PMID:18278581