USP20 Antibody, Biotin conjugated

Code: CSB-PA896876LD01HU

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50μg100μg

US$166

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA

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Target Background

Product Details

Uniprot NO.

Q9Y2K6

Target Names

USP20

Alternative Names

Deubiquitinating enzyme 20 antibody; hVDU2 antibody; KIAA1003 antibody; LSFR 3A antibody; LSFR3A antibody; pVHL interacting deubiquitinating enzyme 2 antibody; Ubiquitin carboxyl terminal hydrolase 20 antibody; Ubiquitin carboxyl-terminal hydrolase 20 antibody; ubiquitin specific peptidase 20 antibody; Ubiquitin specific processing protease 20 antibody; Ubiquitin specific protease 20 antibody; Ubiquitin thioesterase 20 antibody; Ubiquitin thiolesterase 20 antibody; Ubiquitin-specific-processing protease 20 antibody; UBP20_HUMAN antibody; USP 20 antibody; USP20 antibody; VDU 2 antibody; VDU2 antibody; VHL interacting deubiquitinating enzyme 2 antibody; VHL-interacting deubiquitinating enzyme 2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Ubiquitin carboxyl-terminal hydrolase 20 protein (258-417AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Biotin

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Gene References into Functions

USP20 regulates actin cytoskeleton organization and cell migration in a manner dependent on ERK3 expression. The results identify USP20 as a bona fide regulator of ERK3 stability and physiological functions. PMID:28167606
we investigated the inter-action between PKM2 and USP20. Our results suggest a new molecular pathway in cancer metabolism through the regulation of PKM2. PMID:25708858
findings reveal a dynamic regulation of USP20 by site-specific phosphorylation as well as the interdependence of signal transduction and trafficking pathways in balancing adrenergic stimulation and maintaining cellular homeostasis PMID:25666616
data establish a new function of USP20 in genome maintenance and DNA repair. PMID:24923443
Analysis of indel variations in the human disease-associated genes CDKN2AIP, WDR66, USP20 and OR7C2 in a Korean population. PMID:22552337
Our results point to USP20 as a key negative regulator of HTLV-1 Tax-induced NF-kappaB signaling. PMID:21525354
identification and description of VDU2 in human cells PMID:12865408
von Hippel-Lindau protein-interacting deubiquitinating enzyme 2 (VDU2) deubiquitinates and stabilizes HIF-1alpha. PMID:15776016
USPs 20 and 33 serve as novel regulators that dictate both post-endocytic sorting as well as the intensity and extent of beta(2)AR signalling from the cell surface. PMID:19424180

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Subcellular Location

Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=According to PubMed:12865408, it localizes in the endoplasmic reticulum; however the relevance of such result is unclear.

Protein Families

Peptidase C19 family, USP20/USP33 subfamily

Database Links

HGNC: 12619

UNIGENE: Hs.5452

KEGG: hsa:10868

STRING: 9606.ENSP00000313811

OMIM: 615143

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