USP16 Antibody

Code: CSB-PA025706GA01HU

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Size:

100μl

US$600

Quantity:

Species Reactivity: Human,Mouse,Rat

Raised in: Rabbit

Application: ELISA,WB,IHC

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Target Background

Product Details

Uniprot NO.

Q9Y5T5

Target Names

USP16

Alternative Names

Deubiquitinating enzyme 16 antibody; Human ubiquitin processing protease antibody; MSTP039 antibody; Ubiquitin carboxyl-terminal hydrolase 16 antibody; Ubiquitin Specific peptidase 16 antibody; Ubiquitin Specific Protease 16 antibody; Ubiquitin thiolesterase 16 antibody; Ubiquitin-processing protease UBP-M antibody; Ubiquitin-specific-processing protease 16 antibody; UBP M antibody; UBP16_HUMAN antibody; UBPM antibody; usp16 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human USP16

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IHC

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.

Gene References into Functions

USP16 was frequently downregulated. PMID:27633997
USP16 and TTC3 were dysregulated in all affected human cells and two mouse models of Down syndrome. PMID:27586445
The data unveil a unique mechanism by which Usp16 promotes the localization and maintenance of Plk1 on the kinetochores for proper chromosome alignment. PMID:26323689
Data show that histone H2A deubiquitinase USP16 interacts with E3 ubiquitin-protein ligase HERC2, negatively regulates DNA damage-induced ubiquitin foci formation, and is required for termination of the ubiquitin signal. PMID:25305019
S552P disrupts the interaction between Ubp-M and nuclear export protein CRM1, increasing Ubp-M nuclear retention as cells progress into M phase, revealing a critical function for Ubp-M S552P. PMID:24013421
in human tissues overexpression of USP16 reduces the expansion of normal fibroblasts and postnatal neural progenitors, whereas downregulation of USP16 partially rescues the proliferation defects of Down's syndrome fibroblasts PMID:24025767
Study reports the solution structure of the BUZ domain of Ubp-M, a ubiquitin-specific protease, and its interaction with ubiquitin; the Ubp-M BUZ domain features three zinc-binding sites consisting of 12 residues. PMID:17512543
knockdown of Ubp-M in HeLa cells results in slow cell growth rates owing to defects in the mitotic phase of the cell cycle PMID:17914355
a new cryptic USP16-RUNX1 fusion in chronic myelomonocytic leukemia PMID:18925961

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Subcellular Location

Nucleus.

Protein Families

Peptidase C19 family, USP16 subfamily

Tissue Specificity

Present in all the tissues examined including fetal brain, lung, liver, kidney, and adult heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Database Links

HGNC: 12614

UNIGENE: Hs.99819

KEGG: hsa:10600

STRING: 9606.ENSP00000334808

OMIM: 604735

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