UBE2B Antibody

1. These data deepen insights into the vital role of RAD6/translesion synthesis in platinum drug tolerance and reveal clinical benefits of targeting RAD6 with SMI#9 for managing chemoresistant cancers. PMID:28490629
2. These results point to an important role of the affinity between RNF4 and its cognate RAD6B or UBCH5B in governing the multiplicity of substrate ubiquitination. PMID:27678051
3. In conclusion, we reveal that miR-455-5p expression is regulated by the TGF-beta-dependent pathway, which subsequently leads to UBE2B down-regulation and contributes to oral cancer tumourigenesis. PMID:27235675
4. These findings show the importance of Rad6 in ovarian cancer and emphasize the need for further studies of Rad6 as a potential target for the treatment of ovarian cancer. PMID:26679603
5. A novel variant (Chr5.133706925 A > G) residing in the UBE2B gene promoter region confers a high risk for idiopathic azoospermia in a Chinese population. PMID:26223869
6. UBE2B mRNA alterations are associated with severe oligozoospermia in infertile men. PMID:23378580
7. UBE2B polymorphisms g.-293T>G, g.20016A>G and g.9157A>G are not associated with male infertility, and the GA haplotype is likely a protective factor for male fertility in Northeast Chinese men. PMID:23079972
8. beta-catenin and Rad6B interacting regions, were identified. PMID:22705350
9. Hydroquinone could upregulate the expression of Rad6B in L-02 hepatic cells. PMID:19548583
10. The Rad6-Rad18 enzyme plays an essential role in promoting replication through DNA lesions by translesion synthesis in mammalian cells. PMID:22547805
11. Data show that the homodimeric Rad18 RING domain can recruit two Rad6b E2 enzymes, whereas the full-length Rad18 homodimer binds only to a single Rad6b molecule. PMID:21549715
12. Ubc2/Rad6 ser(120) regulates ubiquitin-dependent N-end rule targeting by E3{alpha}/Ubr1 PMID:21041297
13. Rad6B is a fundamental component of postreplication DNA repair and can be used as an independent marker for determining response to neoadjuvant chemotherapy. PMID:19466589
14. MCF10A cells stably transfected with antisense RAD6B display hypersensitivity to damage-inducing drugs. PMID:14981545
15. These data reveal a potentially important role for transcriptionally active beta-catenin in the regulation of Rad6B gene expression, and link aberrant beta-catenin signaling with transcriptional deregulation of Rad6B and breast cancer development. PMID:17050667
16. Findings reveal a positive regulatory feedback loop between Rad6B and beta-catenin and a novel mechanism of beta-catenin stabilization/activation in breast cancer cells. PMID:18339854
17. The SAP domain of RAD18 (residues 248-282) is crucial for binding of RAD18 complexed with RAD6B to DNA substrates. PMID:18363965
18. deletions in this suspected promoter region are associated with increased binding affinity for SP1, and might represent one of several factors required for alteration of UBE2B gene expression PMID:18385908
19. study suggests that the UBE2B gene is associated with male infertility in Indian men PMID:18497339

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HGNC: 12473

UNIGENE: Hs.612096

KEGG: hsa:7320

STRING: 9606.ENSP00000265339

OMIM: 179095