TUBB1 Antibody, HRP conjugated

Code: CSB-PA867148LB01HU

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Size:

50μg100μg

US$166

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA

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Target Background

Product Details

Uniprot NO.

Q9H4B7

Target Names

TUBB1

Alternative Names

2810484G07Rik antibody; beta 1 tubulin antibody; Beta tubulin 1, class VI antibody; Beta-tubulin antibody; Class VI beta tubulin antibody; dJ543J19.4 antibody; M(beta)1 antibody; TBB1_HUMAN antibody; TUBB1 antibody; Tubulin beta 1 class VI antibody; Tubulin beta-1 chain antibody; Tubulin, beta 1 antibody; tubulin, beta1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Tubulin beta-1 chain protein (270-451AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Tested Applications

ELISA

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Gene References into Functions

Neonatal platelets exhibit low levels of the Stx11-Munc18b complex (essential component of the SNARE machinery) and of beta1-tubulin. These developmental deficiencies are associated with defects in platelet adhesion, spreading and secretion. PMID:29044293
novel DCX mutation (p.D90G, NP_000546.2) appeared to be a major causative variant, whereas the novel mutation of TUBB1 (p.R62fsX, NP_110400.1) was found only in patients with more-severe intellectual disability in Familial pachygyria PMID:26743950
Analysis of the TUBB1 gene revealed three known missense variants in heterozygous state which in combination might explain the beta1-tubulin defect. PMID:26540125
TUBB1 R307H SNP is significantly associated with the degree of thrombocytopenia in congenital and acquired platelet disorders, and may affect platelets by altering microtubule behavior. PMID:25529050
Data indicate that ABCB1 protein, beta tubulin I and III (betaI, and betaIII tubulin) might contribute to the multidrug resistance (MDR) of MCF7/DOC and be potential therapeutic targets for overcoming MDR of breast cancer. PMID:24894670
TUBB1 mutation disrupting microtubule assembly impairs proplatelet formation and results in congenital macrothrombocytopenia. PMID:24344610
our findings define beta-tubulin VI as a hematologic isotype with significant genetic variation in humans that may affect the myelosuppresive action of microtubule-binding drugs PMID:22805305
homozygous status of P43 genetic polymorphism causes alterations in platelet ultrastructure PMID:21384078
Studies show that BFBTS bound and modified beta-tubulin at residue Cys12, forming beta-tubulin-SS-fluorobenzyl. PMID:19996274
SLPI localizes in part along the megakaaryocyte and platelet cytoskeleton by virtue of specific interactions with beta1 tubulin. PMID:15315966
the platelet Q43P beta1-tubulin substitution is frequent in the healthy population and may protect men against arterial thrombosis PMID:15956286
The TUBB1 Q43P polymorphism, by causing a lower reactivity in platelets carrying the variant form of b1-tubulin, protects against thrombotic disorders but increases the risk of intracerebral hemorrhage in men. PMID:17488662
biophysical analysis of carboxy-terminal tail conformation of human beta-tubulin isotypes PMID:17993481
Mutation of the beta1-tubulin gene associated with congenital macrothrombocytopenia affecting microtubule assembly. PMID:18849486
TUBB1 Q43P polymorphism does not protect against acute coronary syndrome and premature myocardial infarction. PMID:19132255