TRHR Antibody

1. These results demonstrate for the first time that not only agonist binding but also abundance of some signaling proteins may strongly affect TRH receptor dynamics in the plasma membrane PMID:29137494
2. a unique missense TRHR defect identified in a consanguineous family is associated with central hypothyroidism in homozygotes and hyperthyrotropinemia in heterozygotes, suggesting compensatory elevation of TSH with reduced biopotency; the I131T mutation decreases TRH binding and TRHR-Gq coupling and signaling PMID:28419241
3. rs16892496 polymorphism in the TRHR gene may play a role in FFM variation. PMID:23543262
4. The precoupling of receptors with their cognate G-proteins can contribute to faster G-protein activation and subsequent signal transfer into the cell interior. PMID:22240728
5. Data show that interactions of TRHR with GRKs and phosphatases are determined not simply by the amino acid sequences of the substrates, but by regions outside the cytoplasmic tails. PMID:20345371
6. A mutation in thyrotropin-releasing hormone receptor almost completely prevented receptor phosphorylation. PMID:19906838
7. TRH receptor in adenoma cells plays an important role in the paradoxical GH response to TRH administration in GH cell adenomas. PMID:14599121
8. after agonist-driven receptor internalization, the plasma membrane is replenished with younger receptors, arising either from an intracellular pool or preferential recycling of younger receptors. PMID:15117874
9. Controlled dimerization of the TRH receptor potentiates hormone-induced receptor trafficking. PMID:16020481
10. TRHR gene is an important gene for LBM variation. PMID:19268274
11. analysis of the effect of subcellular trafficking of the TRH receptor PMID:19541745

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HGNC: 12299

UNIGENE: Hs.3022

KEGG: hsa:7201

STRING: 9606.ENSP00000309818

OMIM: 188545