THOP1 Antibody

Code: CSB-PA023508GA01HU

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Size:

100μl

US$600

Quantity:

Species Reactivity: Human,Mouse,Rat

Raised in: Rabbit

Application: ELISA,WB,IHC

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Target Background

Product Details

Uniprot NO.

P52888

Target Names

THOP1

Alternative Names

EC 3.4.24.15 antibody; Endopeptidase 24.15 antibody; EP24.15 antibody; MEPD_HUMAN antibody; MP78 antibody; Thimet oligopeptidase 1 antibody; Thimet oligopeptidase antibody; Thop1 antibody; THOP1_HUMAN antibody; TOP antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human THOP1

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IHC

Protocols

ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments.

Gene References into Functions

Data suggest that three new candidate genes involved in the development of rheumatoid arthritis (RA): ERBB2, TP53 and THOP1. PMID:28148290
THOP1 may have clinical potentials to be employed as a promising biomarker to identify individuals with better prognosis and a novel antitumor agent for therapy of patients with NSCLC PMID:25180910
Low THOP1 expression levels are associated with recurrence of hepatocellular carcinoma. PMID:24604581
TCEP. Data indicate that THIMET-oligopeptidase (TOP) oxidation by H2O2 and high valence states of hemeproteins does not lead to enzyme oligomerization. PMID:24223886
shear-dependent TOP induction down-regulates MHC1 levels, pointing to a role for TOP in the flow-mediated regulation of endothelial immunogenicity PMID:23708739
The semi-quantitative intracellular peptidome analyses of siRNA-transfected HEK293 cells shows that the levels of specific intracellular peptides are either increased or decreased upon EP24.15 inhibition. PMID:22796113
mediates antigen processing that generates cytotoxic T cell epitopes PMID:21151101
human thimet oligopeptidase crystal structure shows substrate recognition, regulation, and localization PMID:14998993
THIMET has a role in degradation of peptides generated by proteasomes PMID:15328361
EP24.15 associates with AT1 and B2 receptors both at the plasma membrane and after receptor internalization PMID:15376229
Mutations at only two residues (Glu-469 and Arg-498) are required to swap specificity with neurolysin, a result that is confirmed by testing the two-mutant constructs. PMID:17251185
increase in THOP1 expression might be part of a compensatory defense mechanism of the brain against an increased Abeta load. PMID:18571100
Over 100 peptides were identified in human embryonic kidney 293 (HEK293) cells that are derived from intracellular proteins; many but not all of these peptides are substrates or products of EP24.15. PMID:19282285
interaction between EP24.15 and calmodulin is regulated within cells and is important for the stimulated secretion of EP24.15 from HEK293 cells. PMID:19614740