TAB3 Antibody, FITC conjugated

Code: CSB-PA850806LC01HU

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50μg100μg

US$166

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Species Reactivity: Human

Raised in: Rabbit

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Target Background

Product Details

Uniprot NO.

Q8N5C8

Target Names

TAB3

Alternative Names

MAP3K7IP 3 antibody; Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 antibody; NAP1 antibody; NF-kappa-B-activating protein 1 antibody; NFkB activating protein 1 antibody; TAB-3 antibody; Tab3 antibody; TAB3_HUMAN antibody; TAK1 binding protein 3 antibody; TAK1-binding protein 3 antibody; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 antibody; TGF-beta-activated kinase 1-binding protein 3 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 protein (361-712AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function(From Uniprot)

Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1.; May be an oncogenic factor.

Gene References into Functions

these results demonstrated that TAB3 may be a promising therapeutic target for the treatment of Esophageal squamous cell carcinoma. PMID:30226617
The combination of WES, genomic triangulation, and systems biology has uncovered perturbations in TGF-beta activated kinase 1 signaling as a novel pathogenic substrate for polyvalvular syndrome. PMID:27452334
Our study provides insights into the mechanism of TAB3 regulating activity and suggests its important implications in triple negative breast cancer metastasis. PMID:27009840
Data show that knockdown of transforming growth factor-activated kinase 1 (TAK1)-binding protein 3 (TAB3) inhibited proliferation of non-small cell lung cancer (NSCLC) cells. PMID:26476534
TAB3 regulated ovarian cancer cell bioactivity and chemotherapy performance via the NF-kappaB pathway. PMID:27651027
Upregulation of miR-532-5p and subsequent suppression of the SESTD1 and TAB3 genes represent an antiviral response aimed at limiting West Nile virus infection. PMID:26676784
miR-30a in MSCs may participate in the immune dysregulation of the maternal-fetal interface during PE PMID:26555189
miR-26b suppresses NF-kappaB signaling and sensitizes hepatocellular carcinoma cells to doxorubicin-induced apoptosis by inhibiting the expression of TAK1 and TAB3. PMID:24565101
conclude that TRIM38 negatively regulates TNFalpha- and IL-1beta-induced signaling by mediating lysosome-dependent degradation of TAB2/3, two critical components in TNFalpha- and IL-1beta-induced signaling pathways PMID:24434549
Studies show that three proteins expressed in HEK-293T cells (NAP1, TANK and TBKBP1) interact with TBK1. PMID:23286385
MiR-23b suppresses IL-17-, tumor necrosis factor alpha (TNF-alpha)- or IL-1beta-induced NF-kappaB activation and inflammatory cytokine expression by targeting TAB2, TAB3 and IKK-alpha. PMID:22660635
human TAB2 and TAB3, ubiquitin-chain sensory proteins involved in NF-kappaB signalling, are directly inactivated by enteropathogenic Escherichia coli NleE, a conserved bacterial type-III-secreted effector responsible for blocking host NF-kappaB signalling PMID:22158122
These results point to the existence of an autophagy-stimulatory 'switch' whereby TAB2 and TAB3 abandon inhibitory interactions with Beclin 1 to engage in a stimulatory liaison with TAK1. PMID:22081109
TAB3 is involved in IL-1-induced NF-kappaB activation by physically linking TAK1 to TRAF6. PMID:14633987
Identification of TAB3 as a binding partner of the protein kinase TAK1. PMID:14670075
TAB3 transforming growth factor is a constituent of the NF-kappaB pathway functioning upstream of tumor necrosis factor alpha-associated factor 6/transforming growth factor beta-activated kinase PMID:14766965
Data show that TAB2 and TAB3 are receptors that bind preferentially to polyubiquitin chains through a highly conserved zinc finger (ZnF) domain, and activate NF-kappa B and IKK. PMID:15327770
The TAB2/TAB3 interaction with TAK1 is crucial for the activation of signaling cascades mediated by interleukin-1, tumor necrosis factor, and receptor activator of nuclear factor-kappa B ligand (RANKL). PMID:17158449