Scgb3a2 Antibody

Code: CSB-PA846028LA01MO

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US$83

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Species Reactivity: Mouse

Raised in: Rabbit

Application: ELISA

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Target Background

Product Details

Uniprot NO.

Q920H1

Target Names

Scgb3a2

Alternative Names

Scgb3a2 antibody; Pnsp1 antibody; Ugrp1 antibody; Secretoglobin family 3A member 2 antibody; Pneumo secretory protein 1 antibody; PnSP-1 antibody; Uteroglobin-related protein 1 antibody

Raised in

Rabbit

Species Reactivity

Mouse

Immunogen

Recombinant Mouse Secretoglobin family 3A member 2 protein (22-139AA)

Immunogen Species

Mus musculus (Mouse)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA

Protocols

ELISA Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Secreted cytokine-like protein. Binds to the scavenger receptor MARCO. Can also bind to pathogens including the Gram-positive bacterium L.monocytogenes, the Gram-negative bacterium P.aeruginosa, and yeast. Strongly inhibits phospholipase A2 (PLA2G1B) activity. Seems to have anti-inflammatory effects in respiratory epithelium. Also has anti-fibrotic activity in lung. May play a role in fetal lung development and maturation. Promotes branching morphogenesis during early stages of lung development. In the pituitary, may inhibit production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).

Gene References into Functions

These results demonstrate that SCGB3A2 has an anti-inflammatory activity in the HDM-induced allergic airway inflammation model, in which SCGB3A2 may modulate the CCR4-CCL17 pathway. PMID:27820933
The pulmonary fibrosis in the Scgb3a2-null mice was more severe than the wild-type controls, thus establishing that SCGB3A2 has anti-fibrotic activity in vivo. PMID:26559674
SCGB3A2 is an anti-fibrotic agent, and suggest a possible therapeutic use of recombinant SCGB3A2 in the treatment of pulmonary fibrosis. PMID:26178733
The results indicate that the loss of SCGB3A2 function was influenced by a modifier gene(s) in mixed genetic background and suggest that SCGB3A2 has anti-inflammatory property. PMID:25242865
SCGB3A2 regulates FSH/LH production in the anterior pituitary lobe. PMID:24514953
Secretoglobin 3A2 suppresses bleomycin-induced pulmonary fibrosis by transforming growth factor beta signaling down-regulation PMID:21478551
Results demonstrate that SCGB3A2 is a useful marker for diagnosis of pulmonary tumors both in mice and humans. PMID:20466451
UGRP1 does not play a major role in the development of bronchial asthma in our Caucasian population. PMID:12915772
results demonstrate that interleukin-10 induces uteroglobin related protein 1(UGRP1) gene expression in lung epithelial cells through transcription factor T/EBP/NKX2.1-dependent pathway PMID:15485815
UGRP1 is downregulated in inflamed airways, such as allergic asthmatics. PMID:15531759
To assess a potential role for SCGB3A2 during early lung development, wild-type and Nkx2-1-null fetal lungs of early developmental stages were subjected to ex vivo organ culture in the presence of SCGB3A2. PMID:18535256
C/EBPalpha and C/EBPdelta have a role in the synergistic interaction with NKX2-1 in mouse Scgb3a2 gene transcription and lung development PMID:18632661
SCGB3A2 gene may contribute to Graves' disease susceptibility. PMID:19126779

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Subcellular Location

Secreted.

Protein Families

Secretoglobin family, UGRP subfamily

Tissue Specificity

Highly expressed in lung where it localizes to epithelial cells of the trachea, bronchus and bronchioles (at protein level). Expressed in club/Clara cells of the bronchioles. Also detected in the anterior and posterior lobes of the pituitary gland where i

Database Links

UNIGENE: Mm.210437

KEGG: mmu:117158

STRING: 10090.ENSMUSP00000038872

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