SZT2 Antibody

Code: CSB-PA735962LA01HU

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20μg50μg100μg

US$83

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA, IHC

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Target Background

Product Details

Uniprot NO.

Q5T011

Target Names

SZT2

Alternative Names

Chromosome 1 open reading frame 84 antibody; FLJ34502 antibody; Hypothetical protein LOC23334 antibody; Protein SZT2 antibody; RP11-506B15.1 antibody; Seizure threshold 2 homolog A antibody; Seizure threshold 2 protein homolog antibody; SZT2 antibody; SZT2_HUMAN antibody; SZT2A antibody; Uncharacterized protein KIAA0467 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Protein SZT2 protein (2396-2517AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA735962LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA735962LA01HU at dilution of 1:100

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Target Background

Function(From Uniprot)

As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. May play a role in the cellular response to oxidative stress.

Gene References into Functions

SZT2 has a central role in dictating GATOR-dependent nutrient sensing by promoting lysosomal localization of SZT2-orchestrated GATOR complex, and reveal an unexpected function of lysosome-located GATOR2 in suppressing mTORC1 signalling through SESN recruitment PMID:28199315
We conclude that the disruption of SZT2 with some residual function might lead to mild or moderate intellectual disability without seizures. PMID:24324832
mutations in SZT2 cause a severe type of autosomal-recessive infantile encephalopathy. PMID:23932106

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Subcellular Location

Lysosome membrane. Peroxisome.

Tissue Specificity

Expressed in the brain, predominantly in the parietal and frontal cortex, as well as in dorsal root ganglia. Expressed in peripheral white blood cells.

Database Links

HGNC: 29040

UNIGENE: Hs.643560

KEGG: hsa:23334

STRING: 9606.ENSP00000457168

OMIM: 615463

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