SUV39H2 Antibody

Code: CSB-PA872500ESR2HU

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20μl50μl100μl

US$83

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA, WB, IHC

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Product Details
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Target Background

Product Details

Uniprot NO.

Q9H5I1

Target Names

SUV39H2

Alternative Names

FLJ23414 antibody; H3 K9 HMTase 2 antibody; H3-K9-HMTase 2 antibody; Histone H3 K9 methyltransferase 2 antibody; Histone H3-K9 methyltransferase 2 antibody; Histone lysine N methyltransferase H3 lysine 9 specific 2 antibody; Histone lysine N methyltransferase SUV39H2 antibody; Histone-lysine N-methyltransferase SUV39H2 antibody; KMT1B antibody; Lysine N methyltransferase 1B antibody; Lysine N-methyltransferase 1B antibody; sSuppressor of variegation 3 9 homolog 2 (Drosophila) antibody; Su(var)3 9 Drosophila homolog of 2 antibody; Su(var)3 9 homolog 2 antibody; Su(var)3-9 homolog 2 antibody; Suppressor of variegation 3 9 homolog 2 antibody; Suppressor of variegation 3-9 homolog 2 antibody; Suv39h2 antibody; SUV92_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Histone-lysine N-methyltransferase SUV39H2 protein (201-410AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western blot
All lanes: Histone-lysine N-methyltransferase SUV39H2 antibody at 0.32μg/ml
Lane 1: HepG2 whole cell lysate
Lane 2: Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 47, 40, 27 kDa
Observed band size: 47 kDa
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA872500ESR2HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA872500ESR2HU at dilution of 1:100

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Target Background

Function(From Uniprot)

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.

Gene References into Functions

Our finding unveils a novel autoregulatory mechanism of SUV39H2 through lysine automethylation PMID:26988914
Our data show that the differential expression of SUV39H1 and SUV39H2 is associated with genomic instability and that the modulation of these HMTases can be an attractive approach to prevent CLL evolution PMID:28833505
SUV39H2 functioned cooperatively with MAGE-A11 to increase androgen-dependent AR transcriptional activity. PMID:28042025
histone H3 lysine 9 methylation reduction, which may be due to the downregulation of methyltransferase SUV39H2 and the upregulation of demethylase KDM4C, was found in CD4(+) T lymphocytes of Latent autoimmune diabetes in adults patients PMID:28396876
data cannot finally exclude H2AX methylation of SUV39H2 in cells, additional experimental evidence is required to validate this claim. PMID:27177470
Our results reveal the regulatory mechanism of LSD1 protein through its lysine methylation by SUV39H2 in human cancer cells PMID:26183527
We also demonstrate that the N324K mutant in the SET domain of SUV39H2 that has been shown to cause an inherited nasal skin disease in Labrador Retrievers renders SUV39H2 inactive PMID:25459750
genetic association studies in a Finnish population with type I diabetes: The minor T allele of exonic SNP rs17353856 in SUV39H2 is associated with diabetic retinopathy (in a larger meta-analysis); thus an genetic variation may be protective. PMID:21896933
findings suggest that Suv39H1 and Suv39H2 are key hypoxia-induced methyltransferases; their decline in fetal lung during late gestation is critical for epigenetic changes resulting in the developmental induction of SP-A PMID:21402781
a novel SUV39H2 polymorphism may have a role in lung cancer susceptibility for smokers PMID:16774942
The SUV39H2 gene is found in tetrapods (e.g., human, mouse and frog) but not in zebrafish, suggesting that this gene is generated by a tetrapod lineage-specific gene duplication event. PMID:18231586