STAM Antibody

Code: CSB-PA724791

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Size:

50μl100μl

US$166

Quantity:

Species Reactivity: Human,Mouse

Raised in: Rabbit

Application: ELISA,IHC

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Target Background

Product Details

Uniprot NO.

Q92783

Target Names

STAM

Alternative Names

DKFZp686J2352 antibody; HSE1 homolog antibody; OTTHUMP00000019237 antibody; Signal transducing adapter molecule 1 antibody; signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 antibody; STAM 1 antibody; STAM antibody; STAM-1 antibody; STAM1_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Fusion protein of Human STAM

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Tested Applications

ELISA,IHC

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Images

The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA724791(STAM Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA724791(STAM Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)

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Target Background

Function(From Uniprot)

Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

Gene References into Functions

The VHS domain of STAM1 directs AMSH to cleave longer Lys63-linked ubiquitin chains PMID:26601948
Differential expression of the transcripts STAM connects ubiquitin-proteasome system with infection-inflammation in preterm births and preterm premature rupture of membranes. PMID:25884766
ESCRT-0 protein hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) is targeted to endosomes independently of signal-transducing adaptor molecule (STAM) and the complex formation with STAM promotes its endosomal dissociation. PMID:25296754
STAM proteins function in a multivalent complex that sorts ubiquitinated proteins into the multivesicular body pathway. PMID:12551915
Interaction of TIMM8a with STAM1. PMID:12745081
Data suggested that association with hepatocyte growth factor-regulated tyrosine kinase substrate is a prerequisite for STAM1 function in early endosome. PMID:15113837
Hrs is a master molecule that controls in part the degradation of STAM1 and the accumulation of ubiquitinated proteins PMID:15640163
Analysis with phospho-specific antibodies indicates that 3 kinases generate a signal-specific, combinatorial phosphorylation profile of the Hrs-STAM complex, with the potential of diversifying tyrosine kinase receptor signalling through a common element. PMID:15828871
The cellular functions of UBPY are complex but clearly distinct from those of the Lys-63-ubiquitin-specific protease, AMSH, with which it shares a binding site on the SH3 domain of STAM PMID:16520378
STAMs function prominently in endoplasmic reticulum-to-Golgi trafficking, most likely through direct interactions with the coat protein II complex PMID:19054391
A novel ubiquitin binding site and the manner of ubiquitin recognition of the STAM1 VHS domain were proposed. PMID:19111546