SMOC1 Antibody, Biotin conjugated

Code: CSB-PA875673LD01HU

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Size:

50μg100μg

US$166

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA

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Target Background

Product Details

Uniprot NO.

Q9H4F8

Target Names

SMOC1

Alternative Names

Secreted modular calcium-binding protein 1 antibody; SMOC-1 antibody; SMOC1 antibody; SMOC1_HUMAN antibody; SPARC-related modular calcium-binding protein 1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human SPARC-related modular calcium-binding protein 1 protein (277-382AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Biotin

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Tested Applications

ELISA

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function(From Uniprot)

Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation.

Gene References into Functions

Missense mutation in exon 3 of SMOC1 segregated with the Waardenburg anophthalmia syndrome in the Iranian family. PMID:28807869
This is the first report of Waardenburg anophthalmia syndrome (WAS) caused by a SMOC1 variant in a Pakistani population. The mutation identified in the present investigation extends the body of evidence implicating the gene SMOC-1 in causing WAS. PMID:28085523
SMOC binds to Pro-EGF, but does not induce Erk phosphorylation via the EGFR. PMID:27101391
IL-17A but not IL-22 suppresses the replication of hepatitis B virus by inducing the expression of MxA and OAS. PMID:23274784
SMOC1 provides a link between prenatal hormone exposure and digit ratio. PMID:23263445
Homozygosity mapping and subsequent targeted mutation analysis of a locus on 14q24.2 identified homozygous mutations in SMOC1 (SPARC-related modular calcium binding 1) in eight unrelated families with Waardenburg Anophthalmia syndrome. PMID:21750680
The present study thus identified SPARC related modular calcium binding 1 as a new cancer-associated protein capable of interacting with tenascin-C in vitro PMID:21349332
these findings indicate that SMOC1/Smoc1 is essential for ocular and limb development in both humans and mice. PMID:21194678
Waardenburg anophthalmia syndrome is genetically heterogeneous; a second was locus found on chromosome 14, and mutations in SMOC1 were shown also cause this syndrome. PMID:21194680
Analyzed the secretory protein profiles of BMSCs grown in osteogenic medium (OSM) and identified SPARC-related modular calcium-binding protein 1 (SMOC1), a member of the SPARC family, as a regulator of osteoblast differentiation of BMSCs. PMID:20359165
isolation of the novel gene SMOC-1 encoding a secreted modular protein containing an EF-hand calcium-binding domain; localization within basement membranes in kidney and skeletal muscle and expression in the zona pellucida surrounding the oocyte PMID:12130637
SMOC-1 is of physiological interest because it codes a secreted glycoprotein with five domains, each containing regions homologous to those on other proteins that mediate cell-matrix interactions. PMID:17386346