SMAD9 Antibody

Code: CSB-PA021794ESR2HU

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Size:

20μl50μl100μl

US$83

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA, WB, IHC

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Target Background

Product Details

Uniprot NO.

O15198

Target Names

SMAD9

Alternative Names

MAD homolog 9 antibody; Madh6 antibody; Mothers against decapentaplegic antibody; Mothers against decapentaplegic homolog 9 antibody; Mothers against DPP homolog 9 antibody; SMAD 9 antibody; SMAD family member 9 antibody; SMAD, mothers against DPP homolog 9 (Drosophila) antibody; SMAD8A antibody; SMAD8B antibody; Smad9 antibody; SMAD9_HUMAN antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Mothers against decapentaplegic homolog 9 protein (1-300AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western blot
All lanes: Mothers against decapentaplegic homolog 9 antibody at 2μg/ml + 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 53, 49 kDa
Observed band size: 53 kDa
Western Blot
Positive WB detected in: HepG2 whole cell lysate
All lanes: SMAD9 antibody at 0.8μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 53, 49 kDa
Observed band size: 53 kDa
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA021794ESR2HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA021794ESR2HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA021794ESR2HU at dilution of 1:100

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Target Background

Function(From Uniprot)

Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD).

Gene References into Functions

Our results exclude a significant role for the SMAD9v90m mutation in juvenile polyposis syndrome PMID:28424237
Mutations in SMAD9 gene encoding for transforming growth factor (TGF)-[beta] superfamily have been identified in Pulmonary Arterial Hypertension. PMID:28582316
Phosphorylated Smad1/5/8/9 specifically bound to the BREs of Smad8/9 gene. The present study reveals that Smad8/9 is a unique R-Smad regulated through the BMP pathway at the mRNA level. PMID:26748560
Case Report: hamartomatous olyposis and gastrointestinal ganglioneuromas with SMAD9 germline mutation that reduces PTEN expression. PMID:26122142
ATP production by NaF promotes hypertrophy-like changes via activation of phospho-Smad8 PMID:23384547
CREBZF, a novel Smad8-binding protein. PMID:22707059
Study described the first mutation in SMAD8 in a patient with IPAH, and suggested the involvement of SMAD8 in the pathogenesis of PAH. PMID:19211612

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Subcellular Location

Cytoplasm. Nucleus.

Protein Families

Dwarfin/SMAD family

Tissue Specificity

Expressed in heart, brain, placenta, lung, skeletal muscle, prostate, testis, ovary and small intestine. Also expressed in fetal brain, lung and kidney.

Database Links

HGNC: 6774

UNIGENE: Hs.123119

KEGG: hsa:4093

STRING: 9606.ENSP00000369154

OMIM: 603295

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