SLC17A3 Antibody, HRP conjugated

Code: CSB-PA021419LB01HU

Rate （N/A）
Review （0）

Size:

50μg100μg

US$166

Quantity:

Species Reactivity: Human

Raised in: Rabbit

Application: ELISA

Send an Inquiry

Start an on-line Chat

Online ordering is currently available for U.S. customers only. For orders outside the U.S., please kindly submit an inquiry or start a chat with us.

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Uniprot NO.

O00476

Target Names

SLC17A3

Alternative Names

SLC17A3 antibody; NPT4 antibody; Sodium-dependent phosphate transport protein 4 antibody; Na(+)/PI cotransporter 4 antibody; Sodium/phosphate cotransporter 4 antibody; Solute carrier family 17 member 3 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Sodium-dependent phosphate transport protein 4 protein (1-125AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA

Protocols

ELISA Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Customer Reviews and Q&A

■ Customer Reviews

Submit a Review here

Target Background

Function(From Uniprot)

voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform 2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na(+) cotransport.

Gene References into Functions

Study used rs548987 of SLC17A3 as a candidate variant of ischemic stroke and performed association analysis in a Chinese population; although rs548987 failed to show significant association with total ischemic stroke and large vessel disease subtype, the C allele of rs548987 showed significant association with small vessel disease subtype of ischemic stroke (OR=0.68, p=0.004). PMID:27772792
hNPT4 (SLC17A3) mediated time- and concentration-dependent uptake of OTxA (K(m): 802.8 microM) in a pH- and voltage-sensitive manner. PMID:21778665
variants carrying SNP V257F, G279R, or P378L exhibited reduced transport of para-aminohippurate, bumetanide, estrone and urate; SNPs may contribute to inter-individual differences in disposition of anionic drugs and certain endogenous organic anions PMID:21282933
Genetic variants within SLC2A9,ABCG2 and SLC17A3 are associated with uric acid levels PMID:20053405
a model of urate secretion in the renal tubular cell, where intracellular urate taken up via OAT1 and/or OAT3 from the blood exits from the cell into the lumen via hNPT4. PMID:20810651
SLC17A3 seems to have a major role in determination of serum uric acid repeated measurements variation. PMID:20162743
mutation reduces the phosphate transport efficiency, possibly modulating the G6-Pase complex PMID:15505377

Hide All

Subcellular Location

[Isoform 1]: Endoplasmic reticulum membrane; Multi-pass membrane protein.; [Isoform 2]: Cell membrane; Multi-pass membrane protein.

Protein Families

Major facilitator superfamily, Sodium/anion cotransporter family

Tissue Specificity

Expressed in the liver and kidney. It is detected in proximal tubules in renal cortex as well as some tubules and glomeruli, with highest expression at the apical side of proximal tubules (at protein level).

Database Links

HGNC: 10931

UNIGENE: Hs.327179

KEGG: hsa:10786

STRING: 9606.ENSP00000380250

OMIM: 611034

Promotions