SIRT4 Antibody

1. structural model of a complex of human Sirt4 and GDH in order to elucidate the molecular mechanism underlying the ADP-ribosylation of GDH by Sirt4 PMID:29571013
2. we propose that the SIRT4-OPA1 axis is causally linked to mitochondrial dysfunction and altered mitochondrial dynamics that translates into aging-associated decreased mitophagy based on an unbalanced mitochondrial fusion/fission cycle. PMID:29081403
3. SIRT4 protein levels in endometrioid adenocarcinoma were markedly lower than its non-neoplastic tissue counterpart (P< 0.001). PMID:28582846
4. Protein levels of SIRT 4 were significantly higher in HUVECs from HELLP pregnancies compared to control after 60 and 120 minutes of hypoxia. PMID:27651178
5. we found that knock-out of mitochondrial sirtuin sir-2.3, homologous to mammalian SIRT4, is protective in both chemical ischemia and hyperactive channel induced necrosis. This work suggests a deleterious role of SIRT4 during ischemic processes in mammals that must be further investigated PMID:28820880
6. miR-15b is a negative regulator of stress-induced SIRT4 expression, thereby counteracting senescence associated mitochondrial dysfunction and regulating the SASP and possibly organ aging, such as photoaging of human skin. PMID:26959556
7. SIRT4 overexpression inhibits the proliferation of colorectal cancer cells in vitro and in vivo. PMID:26986234
8. Thus, these results suggest that SIRT4 has essential roles in stress resistance and may be an important therapeutic target for cancer treatment. PMID:26775843
9. SIRT4 behaves as a tumor suppressor at the human tissue protein level. PMID:26054687
10. Overexpression of SIRT4 attenuated inflammation mediators in umbilical vein endothelial cells. PMID:25331589
11. SIRT4 has a tumour-suppressive function and may serve as a novel therapeutic target in colorectal cancer. PMID:26086877
12. Serum Sirt4 was inversely related to anthropometric and metabolic parameters and positively related to peak GH and IGF-1. PMID:25466907
13. C-terminal-binding protein (CtBP) was found to have an essential role in promoting glutaminolysis by directly repressing the expression of SIRT4. PMID:25633289
14. This study demonstrated that SIRT4 upregulation in the liver of non-alcoholic fatty liver disease patients. PMID:25361925
15. Until now, a mammalian cellular lipoamidase has not been characterized; this study discovered that SIRT4 can function with this enzymatic capacity in the mitochondria, and that PDH is a biological substrate; compared to its catalytic efficiency for deacetylation, SIRT4 exhibits far superior enzymatic activity for lipoyl- and biotinyl-lysine modifications. PMID:25525879
16. The present study shows low circulating levels of SIRT4 in obese patients with nonalcoholic fatty liver disease. PMID:25045415
17. regulates ATP levels via ANT2 and a feedback loop involving AMPK PMID:24296486
18. these results highlight the tumor-suppressive role of SIRT4 in Myc-induced B cell lymphoma and suggest that SIRT4 may be a potential target against Myc-induced and/or glutamine-dependent cancers. PMID:24368766
19. Study shows that mTORC1 promotes glutamine anaplerosis by activating glutamate dehydrogenase (GDH). This regulation requires transcriptional repression of SIRT4, the mitochondrial-localized sirtuin that inhibits GDH. Mechanistically, mTORC1 represses SIRT4 by promoting the proteasome-mediated destabilization of cAMP-responsive element binding 2. PMID:23663782
20. there is a negative correlation between SIRTs 1 and 4 and fasting plasma glucose, a positive correlation between SIRT4 mRNA levels and triglyceride/lipoprotein a levels, and a negative correlation between SIRT4 mRNA levels and HDL PMID:21556116
21. mitochondrial SIRT4 has a role in the regulation of insulin secretion PMID:17715127

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HGNC: 14932

UNIGENE: Hs.50861

KEGG: hsa:23409

STRING: 9606.ENSP00000202967

OMIM: 604482