SHC2 Antibody

Code: CSB-PA008569

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Size:

50μg100μg

US$119

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Species Reactivity: Human,Rat

Raised in: Rabbit

Application: WB, ELISA

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Target Background

Product Details

Uniprot NO.

P98077

Target Names

SHC2

Alternative Names

SHC2 antibody; SCK antibody; SHCB antibody; SHC-transforming protein 2 antibody; Protein Sck antibody; SHC-transforming protein B antibody; Src homology 2 domain-containing-transforming protein C2 antibody; SH2 domain protein C2 antibody

Raised in

Rabbit

Species Reactivity

Human,Rat

Immunogen

Synthesized peptide derived from the Internal region of Human Sck.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Tested Applications

WB, ELISA

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.

Gene References into Functions

Sck was identified as a novel molecule indispensable for CD95's activation of the PI3K and MAPK pathways and induction of cell cycle progression in pancreatic ductal adenocarcinoma. PMID:25613377
SHC2 gene deletions underlie few, if any, cases of well-characterized multiple system atrophy in the US population. PMID:24170347
Data show that copy number loss of SHC2 strongly indicates a causal link to multiple system atrophy. PMID:21658278

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Tissue Specificity

Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.

Database Links

HGNC: 29869

UNIGENE: Hs.30965

KEGG: hsa:25759

STRING: 9606.ENSP00000264554

OMIM: 605217

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