SERPINF2 Antibody

1. alpha2AP has a profibrotic effect probably not by the action as a plasmin inhibitor, and the blocking of alpha2AP exerts an antifibrotic effect in humans and mice with systemic sclerosis PMID:26743600
2. This review presents recent findings regarding the main aspects of the natural heterogeneity of A2AP with particular focus on the functional and possible clinical implications. [review] PMID:26626994
3. Possession of the alpha2AP 407Lys allele was negatively associated with AAA, and thus changes in alpha2AP may affect aneurysm growth and development. PMID:25065555
4. Changes in plasma A2AP are associated with cardiovascular disease event presentation. PMID:26088309
5. A significant correlation was found between soluble fibroblast activation protein levels and alpha2-antiplasmin cleavage in coronary thrombosis. PMID:25464232
6. increased N-terminal cleavage of alpha2AP may have a role in liver cirrhosis PMID:24034420
7. FXIII-A has a functional role through exposure on the activated platelet membrane where it exerts antifibrinolytic function by cross-linking alpha2AP to fibrin PMID:25331118
8. Data suggest serum A2AP (SERPINF2) level can serve as biomarker for diabetic retinopathy; levels of A2AP (but not fibrinogen, plasminogen, or plasminogen activator inhibitor 1) are up-regulated in hyperglycemic type 1 diabetes with retinopathy. PMID:24818165
9. protective mediator during gram-negative (pneumo)sepsis, limiting bacterial growth, inflammation, tissue injury, and coagulation PMID:23992406
10. Study revealed that plasmin was present in tumor tissue, and that it was responsible for processing progalanin to galanin(1-20) in the extracellular environment. PMID:21707521
11. Data suggest that decreased amounts of alpha2-plasmin inhibitor in plasma vs serum ex vivo may reflect reduced factor XIII (FXIII) in vivo; thus, plasma vs serum alpha2-plasmin inhibitor may be useful diagnostic marker for severe FXIII deficiency. PMID:22205503
12. fibrinolysis is enhanced by inhibiting enzymatic cleavage of precursor alpha2-antiplasmin PMID:21251197
13. Truncation of monocyte chemoattractant protein 1 by plasmin promotes blood-brain barrier disruption. PMID:21486949
14. Levels of free full-length alpha2AP were decreased in myocardial infarction (MI); the percentage of C-terminally cleaved alpha2AP was unaltered, and Arg407Lys did not influence alpha2AP levels or MI risk. PMID:21505192
15. the antifibrinolytic function of FXIII is independent of fibrin-fibrin cross-linking and is expressed exclusively through alphaAP. PMID:21471521
16. ADAMTS13 inactivation by plasmin as a potential cause of thrombotic thrombocytopenic purpura PMID:20553378
17. deficiency in patients with Philadelphia chromosome-positive haematologic cancer receiving imatinib mesylate PMID:19492163
18. OPN is highly susceptible to cleavage near its integrin-binding motifs, and the protein is a novel substrate for plasmin and cathepsin D PMID:20071328
19. FXIIIa substrate, A2AP, sequences suggests that the residue located two positions beyond the reactive glutamine is not conserved. this position makes important contributions to effective FXIIIa-A2AP interactions PMID:19691486
20. Multiple Lys residues within alpha 2-antiplasmin contribute, perhaps in a zipper-like fashion, to its binding to the in-tandem, multikringle array that configures the plasmin heavy chain. PMID:12549929
21. Alpha2-antiplasmin has an important role in acute pulmonary embolism PMID:12911586
22. the Arg6Trp polymorphism may play a significant role in governing the long-term deposition/removal of intravascular fibrin PMID:17317851
23. Fibrinolysis is amplified by converting alpha-antiplasmin from a plasmin inhibitor to a substrate PMID:17883703
24. Hydroxyethyl starch (HES) dilution enhances fibrinolysis by diminishing alpha2-antiplasmin-plasmin interactions. PMID:17890952
25. Sequencing analysis revealed the presence of two alpha2-PI gene variations, both in the second half of exon 10: a frameshift mutation and a G to A transition at nucleotide 11337 in codon 407. PMID:17961166
26. Thrombin activatable fibrinolysis inhibitor and alpha(2)-antiplasmin are not markers for recanalization in patients with ischemic stroke treated with recombinant tissue-type plasminogen activator. PMID:18048863
27. Plasmin in nephrotic urine activates the epithelial sodium channel PMID:19073825

Show More

Hide All

HGNC: 9075

UNIGENE: Hs.159509

KEGG: hsa:5345

STRING: 9606.ENSP00000321853

OMIM: 262850