SAE1 Antibody

Code: CSB-PA493084

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Size:

50μl100μl

US$166

Quantity:

Species Reactivity: Human,Mouse,Rat

Raised in: Rabbit

Application: ELISA,WB,IHC

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Product Details
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Target Background

Product Details

Uniprot NO.

Q9UBE0

Target Names

SAE1

Alternative Names

Activator of SUMO1 antibody; AOS1 antibody; HSPC140 antibody; Sae1 antibody; SAE1_HUMAN antibody; Sentrin/SUMO activating protein AOS1 antibody; SUA1 antibody; SUMO 1 activating enzyme E1 N subunit antibody; SUMO 1 activating enzyme subunit 1 antibody; SUMO-activating enzyme subunit 1 antibody; Ubiquitin like protein SUMO1 activating enzyme antibody; Ubiquitin-like 1-activating enzyme E1A antibody; UBL E1A antibody; UBLE1A antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Fusion protein of Human SAE1

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Tested Applications

ELISA,WB,IHC

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA493084(SAE1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA493084(SAE1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
Gel: 15%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 293T cells, A431 cells, Primary antibody: CSB-PA493084(SAE1 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 second

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Target Background

Function(From Uniprot)

The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.

Gene References into Functions

the expression of SENP8, SAE1, PIAS1, PIAS2 and ZMIZ1 is deregulated in the majority of PTC tissues, likely contributing to the PTC phenotype. PMID:26403403
as it has been shown by flow cytometry analysis, specific knockdown of SAE1 slowed down the cell population at G0/G1 phase and induced apoptosis of RKO cells. PMID:25842831
SUMO-1 controls the protein stability and the biological function of phosducin. PMID:16421094

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Subcellular Location

Nucleus.

Protein Families

Ubiquitin-activating E1 family

Tissue Specificity

Expression level increases during S phase and drops in G2 phase (at protein level).

Database Links

HGNC: 30660

UNIGENE: Hs.515500

KEGG: hsa:10055

STRING: 9606.ENSP00000270225