RPS6KA2 Antibody

Code: CSB-PA040257

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Size:

50μg100μg

US$119

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Species Reactivity: Human,Mouse

Raised in: Rabbit

Application: IHC, ELISA

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Target Background

Product Details

Uniprot NO.

Q15349

Target Names

RPS6KA2

Alternative Names

90 kDa ribosomal protein S6 kinase 2 antibody; HU 2 antibody; KS6A2_HUMAN antibody; MAP kinase activated protein kinase 1c antibody; MAP kinase-activated protein kinase 1c antibody; MAPK-activated protein kinase 1c antibody; MAPKAP kinase 1c antibody; MAPKAPK-1c antibody; MAPKAPK1C antibody; Mitogen.activated protein kinase-activated protein kinase 1C antibody; p90 RSK3 antibody; p90-RSK 2 antibody; p90RSK2 antibody; pp90RSK3 antibody; Ribosomal protein S6 kinase alpha-2 antibody; ribosomal protein S6 kinase; 90kDa; polypeptide 2 antibody; Ribosomal S6 kinase 3 antibody; RPS6KA2 antibody; RSK 3 antibody; RSK antibody; RSK-3 antibody; S6K alpha antibody; S6K alpha 2 antibody; S6K-alpha-2 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthesized peptide derived from the Internal region of Human Rsk-3.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Tested Applications

IHC, ELISA

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.

Gene References into Functions

Data suggest that millisecond dynamic changes in PDZ1 domain conformation are responsible for higher affinity of scribble PDZ1 for phosphorylated ligands; oligopeptide fragments of RPS6KA2 and MCC were used as ligands in these nuclear magnetic resonance chemical shift experiments. (RPS6KA2 = ribosomal protein S6 kinase 2; MCC = mutated in colorectal cancer protein) PMID:29144123
Data indicate that S6 kinase 2 (S6K2) can phosphorylate histone H3 at position Thr45, which may play a role during cell proliferation and/or differentiation. PMID:23564320
Kinome screening revealed RPS6KA2 expression, in human pancreatic cancer cells, protects against erlotinib induced apoptosis. PMID:24403857
genetic association study in Han population in China: Data suggest that SNPs in RSK3 (rs2229712) and in MEK1 (rs28730804) demonstrate gene-gene interaction that affects antidepressant drug outcome in female patients with major depressive disorder. PMID:23727904
Overexpression of RSK3 or RSK4 supports tumor cell proliferation upon PI3K inhibition both in vitro and in vivo therby contributing to drug resistance. PMID:23635776
p90RSK2 is dispensable for BCR-ABL-induced myeloid leukemia, but may be required for pathogenesis and lineage determination in FLT3-internal tandem duplication-induced hematopoietic transformation. PMID:21527514
Characterization of the terminal domain as a protein kinase PMID:12016217
chronic activation CREB and p90RSK in the epileptic hippocampus may be closely associated with the histopathological changes of Ammon's horn sclerosis PMID:14646589
The accumulation of S6K2 in the nuclei of cancer cells and the correlation with the expression of PCNA and Ki-67 suggest the involvement of S6K2 in the regulation of malignant growth PMID:15995633
p90Rsk-mediated modulation of Hdm2 nuclear is linked to cytoplasmic shuttling with the diminished ability of p53 to regulate cell cycle checkpoints that ultimately leads to transformation PMID:16621805
The above results suggest that RPS6KA2 is a putative tumour suppressor gene to explain allele loss at 6q27. PMID:16878154
there is a functional link between S6K1 II and CK2 signaling, which involves the regulation of S6K1 II nuclear export by CK2-mediated phosphorylation of Ser-17 PMID:16895915