RFC1 Antibody

Code: CSB-PA005450

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50μg100μg

US$119

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Species Reactivity: Human,Mouse,Rat

Raised in: Rabbit

Application: WB, ELISA

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Target Background

Product Details

Uniprot NO.

P35251

Target Names

RFC1

Alternative Names

A1 140 kDa subunit antibody; A1 antibody; A1 P145 Activator 1 large subunit antibody; Activator 1 140 kDa subunit antibody; Activator 1 large subunit antibody; Activator 1 subunit 1 antibody; DNA binding Protein PO GA antibody; DNA-binding protein PO-GA antibody; MHC binding factor beta antibody; MHCBFB antibody; PO GA antibody; RECC1 antibody; Replication factor C (activator 1) 1, 145kDa antibody; Replication factor C 140 kDa subunit antibody; Replication factor C antibody; Replication factor C large subunit antibody; Replication factor C subunit 1 antibody; Replication factor C1 antibody; RF-C 140 kDa subunit antibody; RFC antibody; RFC1 antibody; RFC1_HUMAN antibody; RFC140 antibody; RFC140 Replication Factor C 140 kDa subunit antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from the Internal region of Human RFC1.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Tested Applications

WB, ELISA

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western Blot analysis of mouse liver mouse kidney cells using RFC1 Polyclonal Antibody

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Target Background

Function(From Uniprot)

The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA.; Interacts with C-terminus of PCNA. 5' phosphate residue is required for binding of the N-terminal DNA-binding domain to duplex DNA, suggesting a role in recognition of non-primer template DNA structures during replication and/or repair.

Gene References into Functions

Human CTF18-RFC clamp-loader complexed with non-synthesising POLE efficiently loads the PCNA sliding clamp. PMID:28199690
RFC depletion had a negative impact on LANA's ability to replicate and maintain viral DNA in cells containing artificial KSHV episomes or in infected cells, leading to loss of virus. PMID:25071216
phosphorylation of serine 51 on hLigI plays a critical role in regulating the interaction between hLigI and RFC, which is required for efficient DNA replication and repair. PMID:22952233
report that the large subunit (RFC1) of replication factor C is cleaved in Hutchinson-Gilford progeria syndrome cells, leading to the production of a truncated RFC1 of ~ 75 kDa PMID:22168243
We identified a variant in each of 3 genes (RFC1, SCN1A, ANPEP) potentially implicated in susceptibility to severe neurological complications in West Nile Virus disease. PMID:21881118
Small interfering RNA-mediated knockdown of RFC1 impairs upstream removal of UV lesions and abrogates the downstream recruitment of DNA polymerase delta. PMID:20713449
analysis of the DNA-bound BRCA1 C-terminal region structure from human replication factor C p140 and model of the protein-DNA complex PMID:20081198
interaction with histone deacetylase HDAC1 PMID:12045192
RFC (p140) has an important role as a regulator of transcription and NF-kappaB activity PMID:12509469
destabilization of the RF-C complex by CDKs may inactivate the RF-C complex at the end of S phase PMID:12947101
NMR resonance assignments of the BRCT region of the large subunit PMID:15772763
Ctf18-RFC interacts physically with pol eta, which allows DNA replication forks to overcome interference by various template structures, including damaged DNA and DNA-protein complexes that maintain chromosome cohesion PMID:17545166
Data show that replication factor C (RFC), via several stimulatory motifs per molecule, potently activates flap endonuclease 1 (FEN1), making RFC a critical partner with FEN1 for the processing of eukaryotic Okazaki fragments. PMID:19208620
a mutant version of hLigI, which mimics the hyperphosphorylated M-phase form of hLigI, does not interact with and is not inhibited by RFC, demonstrating that inhibition of ligation is dependent upon the interaction between hLigI and RFC PMID:19223468