RBM10 Antibody, Biotin conjugated

1. RBM10: Harmful or helpful-many factors to consider. PMID:29274279
2. RBM10 mutations contribute to lung adenocarcinoma pathogenesis. PMID:28091594
3. The high rate of TERT promoter mutations, MED12 mutations, RBM10 mutations, and chromosome 1q gain highlight their likely association with tumor virulence PMID:28634282
4. The well-known high-fidelity RNA splice site recognition by RBM10, and probably by RBM5 and RBM6, can thus be largely rationalized by a cooperative binding action of RRM and ZnF domains PMID:29450990
5. Our work has not only expanded the number of pre-mRNA targets for RBM10, but identified RBM10 as a novel regulator of SMN2 alternative inclusion. PMID:28728573
6. RBM10 functions as a splicing regulator using two RNA-binding units with different specificities to promote exon skipping. PMID:28379442
7. RNA binding motif protein 10 (RBM10) negatively regulates its own mRNA and protein expression and that of RNA binding motif protein 5 (RBM5) by promoting alternative splicing-coupled nonsense-mediated mRNA decay (AS-NMD). PMID:28586478
8. results provide evidence that RBM10 expression, in RBM5-null tumors, may contribute to tumor growth and metastasis. Measurement of both RBM10 and RBM5 expression in clinical samples may therefore hold prognostic and/or potentially predictive value PMID:28662214
9. RBM10-TFE3 is a recurrent gene fusion in Xp11 translocation renal cell carcinoma. PMID:28296677
10. Xp11 translocation renal cell carcinomas with RBM10-TFE3 gene fusion demonstrating melanotic features and overlapping morphology with t(6;11) RCC. PMID:28288037
11. RNA-binding motif 10 messenger RNA and protein were reduced in lung adenocarcinoma tissues, and RNA-binding motif 10 overexpression inhibited lung adenocarcinoma cancer cell malignant behavior in vitro. Molecularly, RNA-binding motif 10 regulates many gene pathways involving in the tumor development or progression. PMID:28347232
12. RBM10-TFE3 fusion variant (from chromosome X paracentric inversion), therefore, appears to be a recurrent molecular event in Xp11.2 RCCs. RBM10-TFE3 fusion should be added in the list of screened fusion transcripts in targeted molecular diagnostic multiplex RT-PCR PMID:26998913
13. RBM10 is a tumor suppressor that represses Notch signaling and cell proliferation through the regulation of NUMB alternative splicing PMID:26853560
14. Src family tyrosine kinase signaling may regulate FilGAP through association with RBM10 PMID:26751795
15. The ability of RBM10v1 to regulate alternative splicing depends, at least in part, on a structural alteration within the second RNA recognition motif domain, and correlates with preferential expression of the NUMB exon 11 inclusion variant. PMID:25889998
16. RBM10 regulates alternative splicing of Fas and Bcl-x genes. PMID:24530524
17. Antagonizes the effects of RBM5, RBM6, and RBM10 in cell colony formation. PMID:24332178
18. This study established RBM10 as an important regulator of alternative splicing, presented a mechanistic model for RBM10-mediated splicing regulation and provided a molecular link to understanding a human congenital disorder. PMID:24000153
19. S1-1 contains multiple nuclear localisation sequence that act cooperatively. PMID:23294349
20. Massively parallel sequencing of exons on the X chromosome identifies RBM10 as the gene that causes a syndromic form of cleft palate. PMID:20451169
21. From these results, it seems that the X-chromosome, through its RBM genes, plays a formerly unknown role in the regulation of programmed cell death (apoptosis) in breast cancer. PMID:16552754
22. S1-1 constitutes hundreds of nuclear domains, which dynamically change their structures in a reversible manner; upon globally reducing RNA polymerase II transcription, S1-1 nuclear bodies enlarge and decrease in number. PMID:18315527
23. results indicate that very few genes are involved in the last steps of the apoptotic cascade in breast cancer, among them one of the X-chromosome RBM family PMID:18820371

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HGNC: 9896

UNIGENE: Hs.401509

KEGG: hsa:8241

STRING: 9606.ENSP00000366829

OMIM: 300080