RAE1 Antibody

Code: CSB-PA019276ESR1HU

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20μl50μl100μl

US$83

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Species Reactivity: Human, Mouse

Raised in: Rabbit

Application: ELISA, WB, IHC

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Product Details
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Target Background

Product Details

Uniprot NO.

P78406

Target Names

RAE1

Alternative Names

dJ481F12.3 antibody; dJ800J21.1 antibody; FLJ30608 antibody; Homolog of yeast Rae1 (Bharathi) mRNA associated protein of 41 kDa (Kraemer) antibody; Homolog of yeast Rae1 mRNA associated protein of 41 kDa antibody; MGC117333 antibody; MGC126076 antibody; MGC126077 antibody; MIG 14 antibody; MIG14 antibody; Migration inducing gene 14 antibody; Mnrp 41 antibody; Mnrp41 antibody; mRNA associated protein mrnp 41 antibody; mRNA binding protein 41 kD antibody; mRNA export factor antibody; mRNA export protein antibody; mRNA-associated protein mrnp 41 antibody; MRNP 41 antibody; MRNP41 antibody; RAE 1 antibody; RAE1 (RNA export 1 S.pombe) homolog antibody; rae1 antibody; RAE1 homolog antibody; Rae1 protein homolog antibody; RAE1 RNA export 1 homolog (S. pombe) antibody; RAE1 RNA export 1 homolog antibody; RAE1L_HUMAN antibody; RNA export 1 antibody; RNA export 1 homolog antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human mRNA export factor protein (1-368AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western blot
All lanes: RAE1 antibody at 4.39μg/ml
Lane 1: Mouse brain tissue
Lane 2: HepG2 whole cell lysate
Lane 3: 293T whole cell lysate
Lane 4: Hela whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 41 kDa
Observed band size: 41, 80 kDa
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA019276ESR1HU at dilution of 1: 100
Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA019276ESR1HU at dilution of 1: 100

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Target Background

Function(From Uniprot)

Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton.

Gene References into Functions

RAE1 overexpression was associated with considerably poorer disease-free survival and distant metastasis-free survival, especially in patients with oestrogen receptor-positive tumours. PMID:28181567
show that USP11 is associated with the mitotic spindle, does not regulate SAC inactivation, but controls ubiquitination of RAE1 at the mitotic spindle, hereby functionally modulating its interaction with Nuclear Mitotic Apparatus protein (NuMA). PMID:29293652
Nuclear export inhibition by ORF10 of human herpesvirus 8 requires an interaction with an RNA export factor, Rae1. PMID:27832591
After PSK administration, INF-g production in CD8(+) T cells increased in mice with cells expressing neither Rae-1 nor H60, but did not change in mice implanted with cells expressing both Rae-1 and H60. We demonstrated that the expression of NKG2DLs affects tumor immunity and the efficacy of immuno therapy in tumor-bearing mouse model PMID:28739693
Vesiculoviral matrix (M) protein occupies nucleic acid binding site at nucleoporin pair (Rae1 * Nup98). PMID:24927547
vesicular stomatitis virus M protein interacted efficiently with Rae1-Nup98 complexes associated with the chromatin fraction of host nuclei, consistent with an effect on host transcription PMID:23028327
mouse cytomegalovirus m152/gp40 interaction with RAE1gamma structural analysis reveals a paradigm for MHC/MHC interaction in immune evasion PMID:23169621
This study established a novel postmitotic function for rae-1 in neuronal development. PMID:22357847
RAE1 transgene orchestrates proper chromosome segregation and NUP98-mediated leukemogenesis. PMID:21467841
In a transgenic mouse model of chronic natural killer NKG2D ligand expression, constant exposure to NKG2D ligand RNA export 1 homolog (Rae-1 epsilon) does not functionally impair NK cells or CD8-positive T cells in the context of viral infection. PMID:20530257
present the crystal structure of human Rae1 in complex with the Gle2-binding sequence (GLEBS) of Nup98 at 1.65 A resolution. Rae1 forms a seven-bladed beta-propeller with several extensive surface loops. PMID:20498086
These data show an association of mrnp41 with MT and, moreover, demonstrate that an intact MT system is necessary for dispersion of mrnp41-containing particles to the cellular periphery PMID:11831386
VSV M protein blocks mRNA export by disrupting Rae1 function, which can be reverted by induction of Rae1 expression. PMID:15629720
A purified Rae1 complex stabilizes microtubules in egg extracts in a RanGTP/importin beta-regulated manner PMID:15851029
point to the Rae1-NuMA interaction as a critical element for normal spindle formation in mitosis PMID:17172455
Retinoic acid downregulates Rae1 leading to APC(Cdh1) activation and neuroblastoma SH-SY5Y differentiation. PMID:18212744